Krukoff T L, Ciriello J, Calaresu F R
J Comp Neurol. 1986 Jan 1;243(1):13-22. doi: 10.1002/cne.902430103.
The distribution of somatostatin-like immunoreactivity (SS) was studied in the spinal cord of untreated cats and of cats that had received colchicine at all levels of the cord. In the dorsal horn small (less than 15 microns in diameter), round neurons were found in Rexed laminae II and III at all levels. At all levels laminae IV-VI contained smaller numbers of immunoreactive neurons that were medium (between 15 and 25 microns in diameter) to large (greater than 25 microns in diameter) in size. In addition, small numbers of medium-sized neurons were observed at the dorsal and dorsomedial borders of the gray and white matter in segments C1-5. In the sacral cord (S1-3), a group of medium-sized bipolar neurons was found in the dorsolateral funiculus. In transverse sections the processes of the neurons in these two latter groups travelled in a direction parallel to the border of the gray and white matter. In the intermediate and central gray matter, in addition to the immunoreactive neurons found in the region of the intermediolateral nucleus and nucleus intercalatus of lamina VII in segments C8 to L4 (Krukoff et al., '85a), lamina VII contained immunoreactive neurons at all levels with the largest number occurring in the thoracic cord. These neurons were medium to large in size and were generally multipolar with processes travelling in all directions. Multipolar small immunoreactive neurons were also found in the central gray region (lamina X) in the thoracic and upper lumbar cord. Finally, small numbers of neurons containing SS were found in the ventral horn of the cervical and upper thoracic cord. These multipolar neurons were medium to large in size. The distribution of nerve terminals and fibers containing SS was similar to that previously described in mice, rats, guinea pigs, and primates. Although the function of somatostatin in the spinal cord is not known, its presence in neurons with short processes suggests that it may act to modify local activity in the regions where it is found, including areas involved in sensory, visceromotor, and motor functions.
在未经处理的猫以及在脊髓各节段均接受过秋水仙碱处理的猫的脊髓中，研究了生长抑素样免疫反应性（SS）的分布情况。在背角，所有节段的雷克斯德板层II和III中均发现了小的（直径小于15微米）圆形神经元。在所有节段，板层IV-VI中含有数量较少的免疫反应性神经元，其大小为中等（直径在15至25微米之间）至大（直径大于25微米）。此外，在C1-5节段的灰质和白质的背侧及背内侧边界处观察到少量中等大小的神经元。在骶髓（S1-3）中，在背外侧索中发现了一组中等大小的双极神经元。在横切面上，后两组神经元的突起沿平行于灰质和白质边界的方向走行。在中间灰质和中央灰质中，除了在C8至L4节段的板层VII中间外侧核和中间插入核区域发现的免疫反应性神经元外（Krukoff等人，'85a），板层VII在所有节段均含有免疫反应性神经元，其中数量最多的位于胸髓。这些神经元大小为中等至大，通常为多极，其突起向各个方向走行。在胸髓和上腰髓的中央灰质区域（板层X）中也发现了多极小免疫反应性神经元。最后，在颈髓和上胸髓的腹角中发现了少量含SS的神经元。这些多极神经元大小为中等至大。含SS的神经终末和纤维的分布与先前在小鼠、大鼠、豚鼠和灵长类动物中描述的相似。尽管脊髓中生长抑素的功能尚不清楚，但其在具有短突起的神经元中的存在表明，它可能起到调节其所在区域局部活动的作用，包括参与感觉、内脏运动和运动功能的区域。
