Yamada Shoko Merrit, Tomita Yusuke, Shibui Soichiro, Kurokawa Takashi, Baba Yasuhisa
Department of Neurosurgery, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan.
Department of Neurology, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan.
J Breast Cancer. 2017 Jun;20(2):212-216. doi: 10.4048/jbc.2017.20.2.212. Epub 2017 Jun 26.
The median time of brain metastasis from the diagnosis of breast cancer is approximately 3 years. In this case report, a 69-year-old woman demonstrated cerebellar ataxia. Brain magnetic resonance imaging revealed enhanced lesions in bilateral cerebellar hemispheres. She had undergone surgery, radiation, and chemotherapy for uterine and breast cancer 24 years prior and 16 years prior, respectively. Although she had not received any anticancer treatment for 10 years, no recurrences were identified using whole body scans. A partial tumor resection was performed and the histological diagnosis was an adenocarcinoma from breast cancer. As no extracranial lesions were found, gamma-knife irradiation was performed, without additional systemic chemotherapy. One month posttreatment, the tumors dramatically reduced in size and the patient completely recovered from cerebellar ataxia. Systemic chemotherapy is not always required for brain metastasis from breast cancer with a long interval period, as long as no evidence of extracranial recurrence is detected.
乳腺癌诊断后发生脑转移的中位时间约为3年。在本病例报告中，一名69岁女性出现小脑共济失调。脑部磁共振成像显示双侧小脑半球有强化病灶。她分别在24年前和16年前接受过子宫癌和乳腺癌的手术、放疗及化疗。尽管她已10年未接受任何抗癌治疗，但全身扫描未发现复发。进行了部分肿瘤切除术，组织学诊断为乳腺癌腺癌。由于未发现颅外病灶，进行了伽玛刀照射，未追加全身化疗。治疗后1个月，肿瘤体积显著缩小，患者小脑共济失调完全恢复。对于间隔期较长的乳腺癌脑转移，只要未检测到颅外复发证据，不一定需要全身化疗。
