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[疫苗学的创新:非洲面临的挑战与机遇]

[Innovations in vaccinology: challenge and opportunities for Africa].

作者信息

Diop Doudou, Sanicas Melvin

机构信息

Centre de Recherche Biomédicale Espoir Pour La Santé (CRB-EPLS), Saint-Louis, Sénégal.

Sanofi Pasteur, Asie, Japon et région du Pacifique, Singapour.

出版信息

Pan Afr Med J. 2017 Apr 25;26:235. doi: 10.11604/pamj.2017.26.235.11527. eCollection 2017.

DOI:10.11604/pamj.2017.26.235.11527
PMID:28690749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5491747/
Abstract

Immunization is undoubtedly one of the most effective and most cost-effective health interventions. Vaccines continue to revolutionize our ability to prevent diseases and improve health. With all the technological advances, we are able to extend the benefits of vaccines to more people and to provide better protection from life-threatening infectious diseases. Nevertheless, thanks to the unceasing implementation of novel microbial strains on a worldwide basis, research in vaccinology must innovate continuously. African countries have made great progress in increasing routine immunization coverage rates and in introducing newly developed vaccines. New types of vaccines associated with vectorization, administration and specific licensing tools as well as with adjuvants designed to finely modulate immune responses are expected to be achieved in the near future. African countries need to work to develop a regional approach to respond effectively to the many challenges. Providing better information, implementing healthcare personnel vaccinology training programs and well targeted research projects are the keys to future achievements in the field.

摘要

免疫接种无疑是最有效且最具成本效益的健康干预措施之一。疫苗不断革新我们预防疾病和改善健康的能力。随着所有技术进步,我们能够将疫苗的益处扩展到更多人,并提供更好的保护以抵御危及生命的传染病。然而,由于在全球范围内不断出现新的微生物菌株,疫苗学研究必须持续创新。非洲国家在提高常规免疫接种覆盖率和引入新研发疫苗方面取得了巨大进展。预计在不久的将来会实现与载体化、给药方式、特定许可工具以及旨在精确调节免疫反应的佐剂相关的新型疫苗。非洲国家需要努力制定区域方法,以有效应对诸多挑战。提供更好的信息、实施医护人员疫苗学培训计划以及针对性强的研究项目是该领域未来取得成就的关键。

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Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study [corrected].A 群脑膜炎奈瑟球菌结合疫苗(PsA-TT)对乍得 A 群脑膜炎奈瑟球菌脑膜炎和带菌的影响:一项社区研究[已更正]。
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