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外用雷帕霉素治疗结节性硬化症的面部血管纤维瘤

Topical rapamycin for facial angiofibromas in tuberous sclerosis complex.

作者信息

Safa Gilles

机构信息

Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.

出版信息

Oxf Med Case Reports. 2017 Jul 4;2017(7):omx029. doi: 10.1093/omcr/omx029. eCollection 2017 Jul.

DOI:10.1093/omcr/omx029
PMID:28690858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5496009/
Abstract

Facial angiofibromas are a common cutaneous manifestation of tuberous sclerosis complex. Although angiofibromas are usually asymptomatic, they can be highly disfiguring and can have a significant impact on patient quality of life. Treatment for facial angiofibromas is challenging. Recently, topical rapamycin has been proposed as an effective option to treat angiofibromas. Herein is reported a case of a 27-year-old woman whose facial angiofibromas were successfully treated with topical rapamycin without relevant side effects.

摘要

面部血管纤维瘤是结节性硬化症常见的皮肤表现。尽管血管纤维瘤通常无症状,但它们可能会严重毁容,并对患者的生活质量产生重大影响。面部血管纤维瘤的治疗具有挑战性。最近,外用雷帕霉素已被提议作为治疗血管纤维瘤的有效选择。本文报道了一例27岁女性,其面部血管纤维瘤通过外用雷帕霉素成功治疗,且无相关副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e7/5496009/9b95bd03373c/omx029f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e7/5496009/9b95bd03373c/omx029f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e7/5496009/9b95bd03373c/omx029f01.jpg

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引用本文的文献

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Pharmaceutics. 2020 Nov 7;12(11):1060. doi: 10.3390/pharmaceutics12111060.

本文引用的文献

1
Analysis of current data on the use of topical rapamycin in the treatment of facial angiofibromas in tuberous sclerosis complex.结节性硬化症面部血管纤维瘤局部使用雷帕霉素治疗的当前数据分析。
J Eur Acad Dermatol Venereol. 2015 Jan;29(1):14-20. doi: 10.1111/jdv.12665. Epub 2014 Aug 29.
2
Topical rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis.外用雷帕霉素:治疗结节性硬化症面部血管纤维瘤的新方法。
Arch Dermatol. 2010 Jul;146(7):715-8. doi: 10.1001/archdermatol.2010.125.
3
Tuberous sclerosis complex: advances in diagnosis, genetics, and management.
结节性硬化症复合体:诊断、遗传学及管理方面的进展
J Am Acad Dermatol. 2007 Aug;57(2):189-202. doi: 10.1016/j.jaad.2007.05.004.