Feng Hao, Zhang Hongxia, He Wen, Zhou Jian, Zhao Xingquan
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
China National Clinical Research Center for Neurological Diseases, Beijing 100050, China.
Biomed Res Int. 2017;2017:7514639. doi: 10.1155/2017/7514639. Epub 2017 Jun 11.
The purpose of this study was to determine whether jugular venous reflux (JVR) is associated with perihematomal edema (PHE) in individuals with intracerebral hemorrhage (ICH). Patients with spontaneous supratentorial ICH within 72 h of symptom onset were enrolled. Baseline brain computed tomography (CT) scan was performed, with a follow-up CT examination at 12 ± 3 days after onset. Jugular venous color Doppler ultrasound was performed at 12 ± 3 days after onset to examine the JVR status. A total of 65 patients with ICH were enrolled. In logistic regression analysis, absolute PHE volume was significantly associated with JVR (OR, 5.46; 95% CI, 1.04-28.63; = 0.044) and baseline hematoma volume (OR, 1.14; 95% CI, 1.03-1.26; = 0.009) within 72 h of onset. It was also correlated with JVR (OR, 15.32; 95% CI, 2.52-92.99; = 0.003) and baseline hematoma volume (OR, 1.14; 95% CI, 1.04-1.24; = 0.006) at 12 ± 3 days after onset. In a similar manner, relative PHE volume was significantly associated with JVR (OR, 14.85; 95% CI, 3.28-67.17; < 0.001) within 72 h of onset and at 12 ± 3 days after onset (OR, 5.87; 95% CI, 1.94-17.77; = 0.002). JVR is associated with both absolute and relative PHE volumes after ICH.
本研究的目的是确定脑出血（ICH）患者的颈静脉反流（JVR）是否与血肿周围水肿（PHE）相关。纳入症状发作72小时内的自发性幕上脑出血患者。进行基线脑部计算机断层扫描（CT），并在发病后12±3天进行随访CT检查。在发病后12±3天进行颈静脉彩色多普勒超声检查以评估JVR状态。共纳入65例ICH患者。在逻辑回归分析中，绝对PHE体积在发病72小时内与JVR（比值比[OR]，5.46；95%置信区间[CI]，1.04 - 28.63；P = 0.044）和基线血肿体积（OR，1.14；95% CI，1.03 - 1.26；P = 0.009）显著相关。在发病后12±3天，它也与JVR（OR，15.32；95% CI，2.52 - 92.99；P = 0.003）和基线血肿体积（OR，1.14；95% CI，1.04 - 1.24；P = 0.006）相关。同样，相对PHE体积在发病72小时内（OR，14.85；95% CI，3.28 - 67.17；P < 0.001）以及发病后12±3天（OR，5.87；95% CI，1.94 - 17.77；P = 0.002）均与JVR显著相关。ICH后JVR与绝对和相对PHE体积均相关。
