Desoize B, Jardillier J C, Kanoun K, Guerin D, Levy M C
J Pharm Pharmacol. 1986 Jan;38(1):8-13. doi: 10.1111/j.2042-7158.1986.tb04458.x.
Microcapsules (5-100 microns) were prepared through interfacial cross-linking of various proteins (human serum albumin, lysozyme, haemoglobin, casein, pepsin) with glutaraldehyde or terephthaloylchloride. Surprisingly they all showed an inhibitory effect on cultured cells in a concentration range of 100 micrograms ml-1 to 10 mg ml-1. This effect seemed non-specific, reversible and to depend on contact with the cell plasma membrane. The electric charges of microcapsules could be involved in the inhibition phenomenon.
通过各种蛋白质（人血清白蛋白、溶菌酶、血红蛋白、酪蛋白、胃蛋白酶）与戊二醛或对苯二甲酰氯进行界面交联制备了微胶囊（5-100微米）。令人惊讶的是，在100微克/毫升至10毫克/毫升的浓度范围内，它们对培养细胞均显示出抑制作用。这种作用似乎是非特异性的、可逆的，且取决于与细胞质膜的接触。微胶囊的电荷可能与抑制现象有关。
