Rubin Jamie E, Ramamurthi Radhamangalam J
From the Department of Anesthesiology and Perioperative Medicine, Oregon Health and Sciences University, Portland, Oregon; and Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California.
A A Case Rep. 2017 Nov 1;9(9):271-273. doi: 10.1213/XAA.0000000000000590.
We describe the case of a 3-week-old boy with pyloric stenosis who presented for laparoscopic pyloromyotomy in the setting of symptomatic transient neonatal myasthenia gravis. The patient received muscle relaxation with rocuronium, and neuromuscular blockade was successfully reversed with sugammadex with recovery guided by train-of-four monitoring. He was extubated uneventfully without complications. Because sugammadex binds directly to rocuronium rather than interfering with acetylcholine metabolism, it might provide a good option for reversal of neuromuscular blockade in transient neonatal myasthenia gravis.
我们描述了一名3周大患有幽门狭窄的男婴的病例，该患儿在出现症状性短暂性新生儿重症肌无力的情况下接受了腹腔镜幽门肌切开术。患者接受了罗库溴铵肌肉松弛，通过四个成串刺激监测指导恢复，使用舒更葡糖成功逆转了神经肌肉阻滞。他顺利拔管，没有并发症。由于舒更葡糖直接与罗库溴铵结合，而不是干扰乙酰胆碱代谢，它可能为短暂性新生儿重症肌无力中神经肌肉阻滞的逆转提供一个很好的选择。
