Bossi Paolo, Cossu Rocca Maria, Corvò Renzo, Depenni Roberta, Guardamagna Vittorio, Marinangeli Franco, Miccichè Francesco, Trippa Fabio
Department of Head and Neck Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Genitourinary Unit, Division of Medical Oncology, European Institute of Oncology, Milan, Italy.
Crit Rev Oncol Hematol. 2017 Aug;116:82-88. doi: 10.1016/j.critrevonc.2017.05.012. Epub 2017 Jun 4.
The intensity of the available treatment approaches for locally-advanced head and neck cancer (HNC) is at the upper limit of tolerance of acute toxicities. Several factors including breakthrough cancer pain, mucositis, dysphagia, local and systemic infections, and nutritional problems are related to treatment intensity. Particularly, pain, as symptom directly associated with the disease or combined with other treatment-related factors, has a major impact on quality of life of HNC patients and ultimately can influence the efficacy of treatments in HNC. Here, a Multidisciplinary Board of Italian Experts has addressed these issues, with the aim to identify the unmet need and appropriate strategies for the maintenance of optimal treatment intensity in HNC.
局部晚期头颈癌（HNC）现有治疗方法的强度已达到急性毒性耐受的上限。包括突破性癌痛、粘膜炎、吞咽困难、局部和全身感染以及营养问题在内的多种因素与治疗强度相关。特别是，疼痛作为与疾病直接相关或与其他治疗相关因素相结合的症状，对HNC患者的生活质量有重大影响，并最终可能影响HNC治疗的疗效。在此，一个意大利专家多学科委员会已着手解决这些问题，旨在确定未满足的需求以及维持HNC最佳治疗强度的适当策略。
