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葡聚糖和糖原机械解聚过程中机械自由基形成的动力学分析

Kinetic analysis of mechanoradical formation during the mechanolysis of dextran and glycogen.

作者信息

Doi Naoki, Sasai Yasushi, Yamauchi Yukinori, Adachi Tetsuo, Kuzuya Masayuki, Kondo Shin-Ichi

机构信息

Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan.

Department of Pharmaceutical Physical Chemistry, Faculty of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.

出版信息

Beilstein J Org Chem. 2017 Jun 19;13:1174-1183. doi: 10.3762/bjoc.13.116. eCollection 2017.

DOI:10.3762/bjoc.13.116
PMID:28694863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5496574/
Abstract

A detailed electron spin resonance (ESR) analysis of mechanically induced free radicals (mechanoradicals) formation of glucose-based polysaccharides, dextran (Dx) and glycogen (Gly) was performed in comparison with amylose mechanoradicals. The ESR spectra of the samples mechanically fractured at room temperature were multicomponent. The radical concentration of Dx and Gly mechanoradicals gradually decreased during vibratory milling after reaching the maximum value. Although the molecular weight of Dx or the particle diameter of Gly steeply diminished until reaching the each maximum value of radical concentration, after that the molecular weight or the particle diameter slowly decreased. These results suggested that Dx and Gly mechanoradicals might be more unstable than amylose radicals possessing an intramolecular helical structure due to the branched structure.

摘要

与直链淀粉机械自由基相比，对基于葡萄糖的多糖、右旋糖酐（Dx）和糖原（Gly）的机械诱导自由基（机械自由基）形成进行了详细的电子自旋共振（ESR）分析。在室温下机械破碎的样品的ESR光谱是多组分的。在达到最大值后，Dx和Gly机械自由基的自由基浓度在振动研磨过程中逐渐降低。尽管Dx的分子量或Gly的粒径在达到自由基浓度的各自最大值之前急剧减小，但此后分子量或粒径缓慢减小。这些结果表明，由于分支结构，Dx和Gly机械自由基可能比具有分子内螺旋结构的直链淀粉自由基更不稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/a6b065ead49a/Beilstein_J_Org_Chem-13-1174-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/418f59625d28/Beilstein_J_Org_Chem-13-1174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/b11653d07a0c/Beilstein_J_Org_Chem-13-1174-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/f6e523d9b7b1/Beilstein_J_Org_Chem-13-1174-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/41f1d06d5d81/Beilstein_J_Org_Chem-13-1174-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/71a3c1b4f94c/Beilstein_J_Org_Chem-13-1174-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/38fea392e35d/Beilstein_J_Org_Chem-13-1174-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/ef8d77283675/Beilstein_J_Org_Chem-13-1174-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/548e44435744/Beilstein_J_Org_Chem-13-1174-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/b992acd9de3c/Beilstein_J_Org_Chem-13-1174-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/a6b065ead49a/Beilstein_J_Org_Chem-13-1174-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/418f59625d28/Beilstein_J_Org_Chem-13-1174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/b11653d07a0c/Beilstein_J_Org_Chem-13-1174-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/f6e523d9b7b1/Beilstein_J_Org_Chem-13-1174-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/41f1d06d5d81/Beilstein_J_Org_Chem-13-1174-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/71a3c1b4f94c/Beilstein_J_Org_Chem-13-1174-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/38fea392e35d/Beilstein_J_Org_Chem-13-1174-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/ef8d77283675/Beilstein_J_Org_Chem-13-1174-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/548e44435744/Beilstein_J_Org_Chem-13-1174-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/b992acd9de3c/Beilstein_J_Org_Chem-13-1174-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2a/5496574/a6b065ead49a/Beilstein_J_Org_Chem-13-1174-g011.jpg

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