Xu Enquan, Liu Jianuo, Liu Han, Wang Xiaobei, Xiong Huangui
Neurophysiology Laboratory, Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha 68198-5880, NE, USA.
College of Pharmacy, University of Nebraska Medical Center Omaha 68198-6125, NE, USA.
Int J Physiol Pathophysiol Pharmacol. 2017 Jun 15;9(3):84-100. eCollection 2017.
Methamphetamine (Meth) is an addictive psychostimulant widely abused around the world. The chronic use of Meth produces neurotoxicity featured by dopaminergic terminal damage and microgliosis, resulting in serious neurological and behavioral consequences. Ample evidence indicate that Meth causes microglial activation and resultant secretion of pro-inflammatory molecules leading to neural injury. However, the mechanisms underlying Meth-induced microglial activation remain to be determined. In this review, we attempt to address the effects of Meth on human immunodeficiency virus (HIV)-associated microglia activation both and . Meth abuse not only increases HIV transmission but also exacerbates progression of HIV-associated neurocognitive disorders (HAND) through activation of microglia. In addition, the therapeutic potential of anti-inflammatory drugs on ameliorating Meth-induced microglia activation and resultant neuronal injury is discussed.
甲基苯丙胺（冰毒）是一种成瘾性精神兴奋剂，在全球范围内被广泛滥用。长期使用冰毒会产生以多巴胺能终末损伤和小胶质细胞增生为特征的神经毒性，导致严重的神经和行为后果。大量证据表明，冰毒会导致小胶质细胞活化并分泌促炎分子，从而导致神经损伤。然而，冰毒诱导小胶质细胞活化的机制仍有待确定。在本综述中，我们试图探讨冰毒对人类免疫缺陷病毒（HIV）相关小胶质细胞活化的影响。滥用冰毒不仅会增加HIV传播，还会通过激活小胶质细胞加剧HIV相关神经认知障碍（HAND）的进展。此外，还讨论了抗炎药物在改善冰毒诱导的小胶质细胞活化及由此导致的神经元损伤方面的治疗潜力。
