Yang Xiangrui, Wu Shichao, Li Yang, Huang Yu, Lin Jinyan, Chang Di, Ye Shefang, Xie Liya, Jiang Yuan, Hou Zhenqing
Institute of Soft Matter and Biomimetics , College of Materials , Xiamen University , Xiamen 361005 , China . Email:
Department of Chemistry , College of Chemistry & Chemical Engineering , Xiamen University , Xiamen 361005 , China.
Chem Sci. 2015 Mar 1;6(3):1650-1654. doi: 10.1039/c4sc03392b. Epub 2015 Jan 6.
Delicate mesoscopic architectures, bearing complex forms with multiple hierarchy levels, lead to significant functions in biogenic minerals. Herein, a bio-inspired approach was developed to fabricate comet-shaped assemblies of an anti-tumor drug - 10-hydroxycamptothecin (HCPT). The anti-solvent co-precipitation of HCPT and the excipient - PEG--PLGA - within the emulsifier leads to the immediate nucleation of comet bundles, followed by a secondary nucleation to generate the comet head, which is an assembly of nanofibers aligned almost in parallel. The continuous manufacturing furnishes drug-excipient hybrid particles with high drug-loading and a sustained drug release profile. This simple and efficient bio-inspired approach led to a promising sustained local drug delivery system, and could be extended to the fabrication of other functional organic materials bearing mesoscopic structural units.
具有复杂形态和多个层次水平的精细介观结构在生物矿物中发挥着重要功能。在此，开发了一种受生物启发的方法来制备抗肿瘤药物10-羟基喜树碱（HCPT）的彗星状聚集体。HCPT与辅料聚乙二醇-聚乳酸-羟基乙酸共聚物（PEG-PLGA）在乳化剂中进行抗溶剂共沉淀，导致彗星束立即成核，随后二次成核生成彗星头部，彗星头部是由几乎平行排列的纳米纤维组成的聚集体。连续制造为药物-辅料混合颗粒提供了高载药量和持续的药物释放曲线。这种简单有效的受生物启发的方法导致了一种有前景的局部药物持续递送系统，并且可以扩展到制备其他具有介观结构单元的功能性有机材料。
