Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Basic Science and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
J Cell Physiol. 2018 Apr;233(4):2752-2758. doi: 10.1002/jcp.26091. Epub 2017 Aug 30.
Platinum-based chemotherapy is often used as a first-line treatment for patient with breast cancer. Platinum agents bind to DNA, forming adducts that contain intra and inter-strand crosslinks. It is possible that genetic variations of the DNA repair pathways may affect the activity, or efficacy of platinum, and hence resistance to platinum chemotherapy may be related to these genetic variants. We have summarized the known variants in the DNA repair pathway that have been reported to predict the response to platinum-based therapy in breast cancer.
铂类化疗常被用作乳腺癌患者的一线治疗。铂类药物与 DNA 结合，形成含有链内和链间交联的加合物。DNA 修复途径的遗传变异可能会影响铂类的活性或疗效，因此对铂类化疗的耐药性可能与这些遗传变异有关。我们总结了已知的 DNA 修复途径中的变异，这些变异已被报道可预测乳腺癌对铂类治疗的反应。
