人淋巴瘤中的碱性磷酸酶和γ-谷氨酰转肽酶

Alkaline phosphatase and gamma glutamyltranspeptidase in human lymphomas.

作者信息

Spinazzè S, Vezzoni M A, Murone M, Banfi E, Giardini R, Stangalini A, Clerici L, Scanni A, Vezzoni P

出版信息

Tumori. 1986 Feb 28;72(1):71-4. doi: 10.1177/030089168607200110.

DOI:10.1177/030089168607200110

Abstract

Alkaline phosphatase (AP) and gamma glutamyltranspeptidase (GGT) were studied in normal lymphoid cells and in 28 cases of human lymphomas (23 of non-Hodgkin's and 5 of Hodgkin's disease). The expression of AP was enhanced in several samples with a high proportion of mature B cells, particularly in centroblastic-centrocytic lymphoma, whereas tissues mainly composed of T cells always showed low levels of this enzyme. GGT levels were high in thymus, as well as in centroblastic-centrocytic lymphoma and other NHL, thus demonstrating no restriction to a particular cell lineage. Some B-cell neoplasms with cellular origin different from that of centroblastic-centrocytic lymphoma, such as chronic lymphocytic leukemia and centrocytic lymphoma, had low levels of both enzymes. The role of investigation with specific antibodies against these two enzymatic activities in the physiology of lymphoma cell membrane is discussed.

摘要

对正常淋巴细胞以及28例人类淋巴瘤（23例非霍奇金淋巴瘤和5例霍奇金病）进行了碱性磷酸酶（AP）和γ-谷氨酰转肽酶（GGT）的研究。在一些成熟B细胞比例较高的样本中，AP的表达增强，尤其在中心母细胞-中心细胞淋巴瘤中，而主要由T细胞组成的组织中该酶水平始终较低。GGT水平在胸腺以及中心母细胞-中心细胞淋巴瘤和其他非霍奇金淋巴瘤中较高，因此表明对特定细胞谱系无限制。一些细胞起源与中心母细胞-中心细胞淋巴瘤不同的B细胞肿瘤，如慢性淋巴细胞白血病和中心细胞淋巴瘤，两种酶的水平都较低。讨论了针对这两种酶活性的特异性抗体研究在淋巴瘤细胞膜生理学中的作用。