Nelson Anita L
a Obstetrics & Gynecology , Western University of Health Sciences , Manhattan Beach , CA , USA.
Expert Opin Drug Deliv. 2017 Sep;14(9):1131-1140. doi: 10.1080/17425247.2017.1353972. Epub 2017 Aug 2.
Globally, intrauterine devices (IUDs) are the second most commonly used form of reversible contraception because of their high efficacy, safety, convenience and cost effectiveness. The levonorgestrel releasing intrauterine system with daily average release of 20 mcg (LNG-IUS 20) is the popular choice because of its favorable bleeding patterns and many noncontraceptive benefits. A three year (LNG-IUS 8) became available three years ago. More recently, the LNG-IUS 12 was added. This new IUD shares a smaller frame, narrow inserter and lower rate of amenorrhea with the LNG-IUS 8, but it offers the five years of contraceptive protection of the LNG-IUS 20. Areas covered: This article provides information on the contraceptive efficacy, safety and tolerability of this new IUS based on approximately 60,000 cycles of use. Where available, the impacts of subject age, parity and body mass index (BMI) on study outcomes are reported. Expert opinion: This new LNG-IUS 12 with mid-dose hormone levels, smaller frame and longer effective life fills a niche that may better meet the needs of women who might appreciate the narrow insertion tube and/or the lower rates of amenorrhea. Cost will ultimately help determine success.
在全球范围内，宫内节育器（IUDs）是第二常用的可逆避孕方式，因其高效、安全、方便且具有成本效益。每日平均释放20微克左炔诺孕酮的宫内节育系统（LNG-IUS 20）是热门选择，因其出血模式良好且有许多非避孕益处。三年前推出了三年期的（LNG-IUS 8）。最近，又增加了LNG-IUS 12。这款新型宫内节育器与LNG-IUS 8相比，框架更小、插入器更窄且闭经率更低，但它提供了与LNG-IUS 20相同的五年避孕保护。涵盖领域：本文基于约60000个使用周期，提供了关于这款新型宫内节育系统的避孕效果、安全性和耐受性的信息。在可行的情况下，报告了受试者年龄、生育次数和体重指数（BMI）对研究结果的影响。专家意见：这款新型LNG-IUS 12激素水平适中、框架更小且有效寿命更长，填补了一个可能更能满足那些可能青睐较窄插入管和/或较低闭经率女性需求的细分市场。成本最终将有助于决定其成功与否。
