Lawal Ismaheel O, Ololade Kehinde O, Lengana Thabo, Reyneke Florette, Ankrah Alfred O, Ebenhan Thomas, Vorster Mariza, Sathekge Mike M
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa.
Hell J Nucl Med. 2017 May-Aug;20(2):128-133. doi: 10.1967/s002449910553. Epub 2017 Jul 12.
In this study we aimed to present our experience on the use of Gallium-68-dotatate with positron emission tomography, computed tomography ( Ga-dotatate PET/CT) in the management of neuroendocrine tumors (NET) and other somatostatin expressing tumors.
We retrospectively reviewed patients with histologically confirmed or biochemically suspected NET and other somatostatin expressing (SSTR) tumors imaged at our department with Ga-dotatate PET/CT. We determined the performance of this imaging technique as well as its impact on patients management. A total of 203 patients were studied: 103 females, 100 males median age 52years.
The commonest tumor type was gastroenteropancreatic NET (41% of patients) and the commonest sites of distant metastases were lymph nodes and the liver 34.0% and 30.5% respectively. Positron emission tomography detected foci of disease in 19 patients where CT was falsely negative. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of Ga-dotatate PET/CT imaging of NET and other SST expressing tumors were 94.16%, 91.89%, 95.55%, 89.47% and 96.55% respectively.
Gallium-68-dotatate PET/CT was better than CT in detecting primary sites of the disease and highly sensitive and specific for diagnosis and treatment of NET and other SSTR expressing tumors.
在本研究中，我们旨在介绍我们使用镓-68-奥曲肽正电子发射断层扫描、计算机断层扫描（镓-奥曲肽PET/CT）管理神经内分泌肿瘤（NET）和其他表达生长抑素的肿瘤的经验。
我们回顾性分析了在我院接受镓-奥曲肽PET/CT检查的组织学确诊或生化疑似NET及其他表达生长抑素（SSTR）肿瘤的患者。我们确定了这种成像技术的性能及其对患者管理的影响。共研究了203例患者：女性103例，男性100例，中位年龄52岁。
最常见的肿瘤类型是胃肠胰神经内分泌肿瘤（占患者的41%），远处转移最常见的部位是淋巴结和肝脏，分别为34.0%和30.5%。正电子发射断层扫描在19例CT检查结果为假阴性的患者中检测到了病灶。镓-奥曲肽PET/CT对NET和其他表达SST的肿瘤成像的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为94.16%、91.89%、95.55%、89.47%和96.55%。
镓-68-奥曲肽PET/CT在检测疾病原发部位方面优于CT，对NET和其他表达SSTR的肿瘤的诊断和治疗具有高度敏感性和特异性。
