Haug A R, Assmann G, Rist C, Tiling R, Schmidt G P, Bartenstein P, Hacker M
Klinik und Poliklinik für Nuklearmedizin, Klinikum der Ludwigs-Maximilians-Universität München, Campus Grosshadern, Marchioninistr. 15, 81377, München, Deutschland.
Radiologe. 2010 Apr;50(4):349-54. doi: 10.1007/s00117-009-1972-2.
The immunohistochemical expression of somatostatin receptor (SSTR) subtype 2 was compared to quantitative (68)Ga-DOTATATE PET in neuroendocrine tumors (NET).
In 27 patients suffering from metastatic NET the expression of somatostatin receptors (SSTR, score 0-3) and the Ki-67 index were assessed. The immunohistochemical findings were compared with the (68)Ga-DOTATATE PET uptake in these tumors using the SUV(max) (standardized uptake value). Both values were compared with the Ki-67 proliferation index.
The SUV(max) in NET without SSTR expression was significantly lower compared to those with SSTR expression (p <0.05), even though 3 out of 5 NETs with a score of 0 showed a high uptake of (68)Ga-DOTATATE. The SUV(max) correlated significantly (r=0.40, p <0.05) with the score of immunohistochemical SSTR expression (negative, score 0, moderate, score 1 and high, scores 2 and 3). The Ki-67 index correlated inversely with the SSTR expression score (r=-0.42, p <0.05), but not significantly with the SUV(max) (r=-0.33, p=0.11).
(68)Ga-DOTATATE uptake was moderately correlated with the results of immunohistochemical SSTR analyses. However, SSTR negative NET may show high uptake of (68)Ga-DOTATATE.
比较生长抑素受体（SSTR）2型在神经内分泌肿瘤（NET）中的免疫组化表达与定量（68）Ga-DOTATATE PET检查结果。
对27例转移性NET患者评估生长抑素受体的表达（SSTR，评分0 - 3）和Ki-67指数。将免疫组化结果与这些肿瘤的（68）Ga-DOTATATE PET摄取情况（使用SUV（max），即标准化摄取值）进行比较。将这两个值与Ki-67增殖指数进行比较。
与有SSTR表达的NET相比，无SSTR表达的NET的SUV（max）显著更低（p <0.05），尽管5例评分为0的NET中有3例显示（68）Ga-DOTATATE摄取较高。SUV（max）与免疫组化SSTR表达评分（阴性，评分为0；中度，评分为1；高，评分为2和3）显著相关（r = 0.40，p <0.05）。Ki-67指数与SSTR表达评分呈负相关（r = -0.42，p <0.05），但与SUV（max）无显著相关性（r = -0.33，p = 0.11）。
（68）Ga-DOTATATE摄取与免疫组化SSTR分析结果呈中度相关。然而，SSTR阴性的NET可能显示出较高的（68）Ga-DOTATATE摄取。
