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脂质体的治疗前景(作者译)

[Therapeutics future of liposomes (author's transl)].

作者信息

Portal A, Duron F, Aubert P

出版信息

Nouv Presse Med. 1979 May 12;8(21):1749-52.

PMID:286979
Abstract

The possibility to use the liposomes as drug vehicles has been largely investigated in recent years. Most of the studies have been carried out in animals and are related to disease involving predominantly the reticulohistiocytic system. Attempts to use these liposomes orally (induced diabetes) or locally (induced arthritis) are also reported. Further trials are required to get a better knowledge of the mechanisms involved in the exchanges between the cell membrane and the liposome the latter being variable as regards its composition, size and permeability according to the various investigators; the adjustment to the liposome of a complex capable to electively direct it towards the target organ is studied.

摘要

近年来,将脂质体用作药物载体的可能性已得到大量研究。大多数研究是在动物身上进行的,且与主要累及网状组织细胞系统的疾病有关。也有关于口服(诱导糖尿病)或局部(诱导关节炎)使用这些脂质体的尝试的报道。需要进一步试验,以更好地了解细胞膜与脂质体之间交换所涉及的机制,根据不同研究者的研究,脂质体在组成、大小和渗透性方面各不相同;还在研究对脂质体进行调整,使其能够与一种复合物结合,从而选择性地将其导向靶器官。

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