Williams A F, Tse A G
Biosci Rep. 1985 Oct-Nov;5(10-11):999-1005. doi: 10.1007/BF01119912.
The Thy-1 glycoprotein is a very abundant cell surface molecule of rat thymocytes and neuronal cells with the properties of a molecule that inserts into the lipid bilayer. The hydrophobicity is due to a glycophospholipid component covalently attached to the carboxy group of the C-terminal cysteine residue. The mature glycoprotein does not contain a stretch of hydrophobic amino acids that could traverse the membrane bilayer. These findings present a new mode of membrane attachment for a cell surface molecule that can mediate lymphokine release and cell division after cross-linking by antibodies.
Thy-1糖蛋白是大鼠胸腺细胞和神经元细胞中一种非常丰富的细胞表面分子，具有插入脂质双层的分子特性。其疏水性归因于一个共价连接到C末端半胱氨酸残基羧基上的糖磷脂成分。成熟的糖蛋白不含可穿越膜双层的一段疏水氨基酸。这些发现为一种细胞表面分子呈现了一种新的膜附着模式，该分子在被抗体交联后可介导淋巴因子释放和细胞分裂。
