Inflammation, Repair & Development Section, National Heart & Lung Institute, Imperial College London and Dept of Respiratory Paediatrics, Royal Brompton Hospital London, United Kingdom.
Paediatr Respir Rev. 2017 Sep;24:11-13. doi: 10.1016/j.prrv.2017.06.001. Epub 2017 Jun 12.
Severe asthma in children is characterised by severe and multiple aeroallergen sensitisation, food allergy, eosinophilic airway inflammation and airway remodelling. However, it is a heterogeneous disease with considerable variability in the manifestation of each of these characteristics between patients. Recent data from mechanistic studies that have used translational approaches including neonatal mouse models and airway bronchoscopic samples, have shown specific molecular mediators that drive remodelling and steroid resistance in paediatric severe asthma will be discussed. The importance of undertaking studies using age appropriate models and primary cells from children to identify novel therapeutic targets will be highlighted.
儿童重症哮喘的特征是严重且多重的变应原致敏、食物过敏、嗜酸性气道炎症和气道重塑。然而，这是一种异质性疾病，在患者之间，这些特征的每一种表现都存在相当大的变异性。最近，一些使用转化方法的机制研究数据，包括新生儿小鼠模型和气道支气管镜样本，已经显示出特定的分子介质，这些介质在儿科重症哮喘中驱动重塑和类固醇耐药性。强调使用适合年龄的模型和儿童原代细胞进行研究以确定新的治疗靶点的重要性。
