[前列腺素E2与人甲状腺组织中受体的相互作用及其对腺苷酸环化酶活性的影响]
[Interaction of prostaglandin E2 with receptors and their effect on adenylate cyclase activity in human thyroid tissue].
作者信息
Gal'chinskaia V Iu, Rom-Bugoslavskaia E S, Lille Iu E
出版信息
Biull Eksp Biol Med. 1986 Mar;101(3):306-9.
The investigations have been performed on thyroid tissue excised from patients suffering from euthyroid goiter and thyrotoxicosis. The study of thyroid thyrotoxic tissue has revealed the decrease in the number of free receptors to 3H-PGE2 caused by the enhanced production of receptor-endogenous PGE2 complexes whose level in thyrotoxic tissue was significantly higher than in euthyroid tissue. PGE2 and GppNHp had a pronounced stimulating effect on adenylate cyclaze activity both in euthyroid and thyrotoxic tissues, with enzyme sensitivity to stimulating effects considerably increased in the latter case.
已对从患有甲状腺功能正常的甲状腺肿和甲状腺毒症患者切除的甲状腺组织进行了研究。对甲状腺毒症组织的研究表明，由于受体 - 内源性PGE2复合物的产生增加，导致对3H - PGE2的游离受体数量减少，甲状腺毒症组织中该复合物的水平明显高于甲状腺功能正常的组织。PGE2和GppNHp对甲状腺功能正常和甲状腺毒症组织中的腺苷酸环化酶活性均有明显的刺激作用，在后一种情况下，酶对刺激作用的敏感性显著增加。
Zotero 插件