从大鼠前额叶皮质到中脑导水管周围灰质的兴奋性氨基酸投射。
An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray.
作者信息
Christie M J, James L B, Beart P M
出版信息
Brain Res Bull. 1986 Jan;16(1):127-9. doi: 10.1016/0361-9230(86)90020-1.
High affinity D-[3H]aspartate and [3H]GABA uptake, and amino acid concentrations were examined in synaptosome-enriched preparations of rat periaqueductal gray matter 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H]aspartate (78% of control, p less than 0.025), but not of [3H]GABA. Concentrations of glutamate, aspartate, GABA, glycine and alanine were not significantly reduced in lesioned animals. These results suggest the presence of glutamatergic and/or aspartatergic projections from medial prefrontal cortex to periaqueductal grey matter.
在局限于内侧前额叶皮质的N-甲基-D-天冬氨酸损伤6-7天后，检测了大鼠导水管周围灰质富含突触体的制剂中高亲和力D-[3H]天冬氨酸和[3H]GABA的摄取以及氨基酸浓度。观察到D-[3H]天冬氨酸的高亲和力摄取有特异性降低（为对照的78%，p<0.025），但[3H]GABA的摄取未降低。损伤动物中谷氨酸、天冬氨酸、GABA、甘氨酸和丙氨酸的浓度没有显著降低。这些结果表明存在从内侧前额叶皮质到导水管周围灰质的谷氨酸能和/或天冬氨酸能投射。
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