Jones C R, Giembcyz M, Hamilton C A, Rodger I W, Whyte K, Deighton N, Elliott H L, Reid J L
Clin Sci (Lond). 1986 Feb;70(2):147-53. doi: 10.1042/cs0700147.
The effect of intravenous infusion of catecholamines and related drugs on human platelet alpha 2-adrenoceptor number and function was investigated. Short (60-120 min) infusions of catecholamines with alpha 2 agonist activity in vivo produced attenuation of the platelet responses to adrenaline in vitro. This desensitization was specific for the adrenaline induced aggregatory response. The maximum number of [3H]yohimbine binding sites on platelets was not altered by adrenaline infusion. The ability of adrenaline to reduce platelet cyclic AMP levels was significantly reduced after the infusions. Acute infusions of alpha 2-adrenoceptor agonists may alter the coupling of the platelet alpha 2-adrenoceptor to adenylate cyclase.
研究了静脉输注儿茶酚胺及相关药物对人血小板α2-肾上腺素能受体数量和功能的影响。体内短时间（60 - 120分钟）输注具有α2激动剂活性的儿茶酚胺会使体外血小板对肾上腺素的反应减弱。这种脱敏作用对肾上腺素诱导的聚集反应具有特异性。输注肾上腺素后，血小板上[3H]育亨宾结合位点的最大数量未发生改变。输注后，肾上腺素降低血小板环磷酸腺苷水平的能力显著降低。急性输注α2-肾上腺素能受体激动剂可能会改变血小板α2-肾上腺素能受体与腺苷酸环化酶的偶联。
