前列腺素E2（PGE2）对海蟾蜍离体胃肌层肌肉中乙酰胆碱引发的收缩的影响。

The influence of prostaglandin E2 (PGE2) on the acetylcholine-initiated contractions of isolated gastric muscularis muscle of Bufo marinus.

作者信息

Tsai C S, Ochillo R F

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;83(1):211-5. doi: 10.1016/0742-8413(86)90038-1.

Abstract

Acetylcholine (ACh) (1.5 X 10(-5) M) elicited three different types of tonic and phasic contraction of muscularis muscle from different parts (cardiac, middle and pyloric) of the stomach of Bufo marinus. Prostaglandin E2 (PGE2) (10(-9)-10(-6) M) induced a concentration-dependent relaxation of tonic contractions elicited by ACh (1.5 x 10(-5) M) of strips from the cardiac part while potentiating the phasic contractions from the middle part of the stomach. PGE2 (10(-7) M) relaxed tonic contraction and potentiated phasic contraction concomitantly in preparations in which tonic and phasic contractions were elicited by ACh (1.5 x 10(-5) M). The effects of PGE2 on the preparation are related to the part of the stomach from where the strips are prepared and the muscle tone of the preparation.

摘要

乙酰胆碱（ACh）（1.5×10⁻⁵ M）可引起海蟾蜍胃不同部位（贲门、中间和幽门）肌层肌肉出现三种不同类型的紧张性和阶段性收缩。前列腺素E2（PGE2）（10⁻⁹ - 10⁻⁶ M）可使贲门部肌条由ACh（1.5×10⁻⁵ M）引起的紧张性收缩产生浓度依赖性舒张，同时增强胃中间部的阶段性收缩。在由ACh（1.5×10⁻⁵ M）引起紧张性和阶段性收缩的标本中，PGE2（10⁻⁷ M）可同时使紧张性收缩舒张并增强阶段性收缩。PGE2对标本的作用与制备肌条的胃的部位以及标本的肌张力有关。