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Sub-therapeutic darunavir concentration and garlic consumption; a «Mediterranean» drug-food interaction, about 2 cases.

作者信息

Cloarec N, Solas C, Ladaique A, Tamalet C, Zaegel-Faucher O, Bregigeon S, Canet B, Cano C E, Poizot-Martin Isabelle

机构信息

Aix-Marseille University, Marseille, France.

APHM- Sainte-Marguerite Hospital, Department of Immuno-Haematology/HIV, Aix-Marseille University, 13274, Marseille, France.

出版信息

Eur J Clin Pharmacol. 2017 Oct;73(10):1331-1333. doi: 10.1007/s00228-017-2300-9. Epub 2017 Jul 11.

DOI:10.1007/s00228-017-2300-9
PMID:28699073
Abstract
摘要

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本文引用的文献

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An unusual case of HIV virologic failure during treatment with boosted atazanavir.
AIDS. 2013 May 15;27(8):1361-2. doi: 10.1097/QAD.0b013e32835fac84.
2
HIV protease inhibitors: garlic supplements and first-pass intestinal metabolism impact on the therapeutic efficacy.HIV 蛋白酶抑制剂：大蒜补充剂和首过肠道代谢对治疗效果的影响。
Biopharm Drug Dispos. 2010 Nov;31(8-9):495-505. doi: 10.1002/bdd.730. Epub 2010 Oct 26.
3
Effects of Garlic on Cytochromes P450 2C9- and 3A4-Mediated Drug Metabolism in Human Hepatocytes.大蒜对人肝细胞中细胞色素P450 2C9和3A4介导的药物代谢的影响。
Sci Pharm. 2010 Jul-Sep;78(3):473-81. doi: 10.3797/scipharm.1002-11. Epub 2010 Jun 9.
4
Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans.大蒜提取物诱导肠道 P-糖蛋白，但对人类肠道和肝脏 CYP3A4 没有影响。
Eur J Pharm Sci. 2010 Dec 23;41(5):729-35. doi: 10.1016/j.ejps.2010.09.016. Epub 2010 Oct 7.
5
Garlic flavonoids and organosulfur compounds: impact on the hepatic pharmacokinetics of saquinavir and darunavir.大蒜类黄酮和有机硫化合物：对沙奎那韦和达芦那韦肝药代动力学的影响。
Drug Metab Pharmacokinet. 2010;25(6):521-30. doi: 10.2133/dmpk.dmpk-10-rg-053. Epub 2010 Oct 1.
6
The influence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices.大蒜提取物对 HepG2 细胞和大鼠肝切片摄取沙奎那韦和达芦那韦的影响。
Drug Metab Pharmacokinet. 2010;25(3):307-13. doi: 10.2133/dmpk.25.307.
7
The effect of garlic supplements on the pharmacokinetics of saquinavir.大蒜补充剂对沙奎那韦药代动力学的影响。
Clin Infect Dis. 2002 Jan 15;34(2):234-8. doi: 10.1086/324351. Epub 2001 Dec 5.
8
An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic.大蒜对人细胞色素P450 3A4和P-糖蛋白抑制作用的体外评价
J Pharm Pharm Sci. 2001 May-Aug;4(2):176-84.