Wu Ruey-Shyuan, Liu Yi-Jing, Chu Che-Chu, Heng Hock Gan, Chia Min-Yuan, Wang Hsien-Chi, Chen Kuan-Sheng
Veterinary Medical Teaching Hospital, College of Veterinary Medicine, National Chung Hsing University, Taichung, 402, Taiwan.
Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, 402, Taiwan.
Vet Radiol Ultrasound. 2017 Sep;58(5):607-612. doi: 10.1111/vru.12522. Epub 2017 Jul 11.
Insulinoma is a functional, insulin-secreting tumor, arising from the beta islet cells of the pancreas. It is one of the most common neoplasms in ferrets and has been associated with clinical signs of hypoglycemia, such as ptyalism, pawing at the mouth, seizures, lethargy, and coma. The ultrasonographic features of insulinoma in ferrets have not been previously reported. The purpose of this retrospective case series study was to describe the ultrasonographic features of confirmed insulinoma in a group of ferrets. Inclusion criteria were abdominal ultrasound examination and histological confirmed insulinoma by surgical biopsy. Six ferrets met the inclusion criteria, all of which had multiple hypoglycemic episodes. Ultrasonographic images were reviewed and the characteristics of the pancreatic nodules were recorded. Twenty-eight pancreatic nodules were observed in the six ferrets and were primarily hypoechoic (89.3%, 25/28) and homogenous (46.4%, 13/28) with a smooth margin (78.6%, 22/28). The distribution of the pancreatic nodules was 46.4% in the left lobe, 50% in the right lobe, and 3.6% in the body of the pancreas. The sizes of the pancreatic nodules varied from 1.5 × 1.5 to 4.1 × 5.6 mm. All of the pancreatic nodules removed from surgery were histopathologically confirmed as insulinoma. The findings indicated that insulinoma in ferrets could be detected through ultrasonography, which may facilitate diagnosis and preoperative surgical planning.
胰岛素瘤是一种功能性的、分泌胰岛素的肿瘤，起源于胰腺的β胰岛细胞。它是雪貂中最常见的肿瘤之一，与低血糖的临床症状有关，如流涎、用爪子抓嘴、癫痫发作、嗜睡和昏迷。雪貂胰岛素瘤的超声特征此前尚未见报道。本回顾性病例系列研究的目的是描述一组雪貂中经确诊的胰岛素瘤的超声特征。纳入标准为腹部超声检查以及通过手术活检组织学确诊为胰岛素瘤。六只雪貂符合纳入标准，它们均有多次低血糖发作。对超声图像进行了回顾，并记录了胰腺结节的特征。在这六只雪貂中观察到28个胰腺结节，这些结节主要为低回声（89.3%，25/28）且均匀（46.4%，13/28），边缘光滑（78.6%，22/28）。胰腺结节的分布为左叶46.4%，右叶50%，胰体3.6%。胰腺结节的大小从1.5×1.5至4.1×5.6毫米不等。所有手术切除的胰腺结节经组织病理学确诊为胰岛素瘤。这些发现表明，雪貂中的胰岛素瘤可通过超声检查检测到，这可能有助于诊断和术前手术规划。
