Roberts Kate, Culleton Vanessa, Lwin Zarnie, O'Byrne Kenneth, Hughes Brett Gm
Cancer Care Services, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Asia Pac J Clin Oncol. 2017 Aug;13(4):277-288. doi: 10.1111/ajco.12698. Epub 2017 Jul 12.
Immune checkpoint inhibitors have recently emerged as an exciting new treatment paradigm across a broad spectrum of malignancies. This new class of agents also challenges oncologists with a unique set of immune-based toxicities. Early recognition and precise management of these toxicities can result in better outcomes, with minimization of toxicity and harm to the patient. This article provides a comprehensive review of immune-based toxicities caused by immune checkpoint inhibitors, including recommendations for their investigation and guidelines for specific management.
免疫检查点抑制剂最近已成为一种令人兴奋的新型治疗模式，适用于广泛的恶性肿瘤。这类新型药物也给肿瘤学家带来了一系列独特的基于免疫的毒性挑战。对这些毒性的早期识别和精确管理可带来更好的治疗效果，同时将毒性和对患者的伤害降至最低。本文全面综述了免疫检查点抑制剂引起的基于免疫的毒性，包括对其检查的建议和具体管理指南。
