Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35100 Izmir, Turkey.
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Katip Celebi University, Balatcik 35620 Cigli Izmir, Turkey.
Curr Med Chem. 2018;25(33):4084-4101. doi: 10.2174/0929867324666170711114336.
Latest data from International Agency for Cancer Research shows that breast cancer is the leading cancer site in women and is the leading cause of death among female cancers. Induction of reactive oxygen species (ROS) and oxidative stress as a consequence of impaired balance between prooxidants and antioxidants are suggested to be involved in induction and progression of breast cancer. Cancer cells are found to exhibit higher levels of ROS compared to normal cells. However increased antioxidant defence which balances the oxidative status within the cancer cells suggests that high ROS levels may prevent tumorigenesis via various mechanisms. These contradictory roles of ROS and oxidative stress in breast cancer let scientists investigate potential oxidative stress modulators as anticancer strategies.
In the present review we address the mechanisms of ROS production in breast cancer cells, the role of impaired oxidative status as well as the benefits of introducing oxidative stress modulators in therapeutic strategies in breast cancer. This review is focusing more on melatonin which we have been working on during the last decade. Our data, in accordance with the literature, suggest an important role for melatonin in breast cancer prevention and adjuvant therapy.
国际癌症研究机构的最新数据显示，乳腺癌是女性中最常见的癌症部位，也是女性癌症死亡的主要原因。活性氧（ROS）的产生和氧化应激的发生，是由于抗氧化剂和氧化剂之间的平衡受损，被认为与乳腺癌的发生和发展有关。与正常细胞相比，癌细胞中发现 ROS 水平更高。然而，高抗氧化防御能力可以平衡癌细胞内的氧化状态，这表明高 ROS 水平可能通过多种机制阻止肿瘤发生。ROS 和氧化应激在乳腺癌中的这种矛盾作用，使科学家们将潜在的氧化应激调节剂作为抗癌策略进行研究。
在本综述中，我们探讨了乳腺癌细胞中 ROS 产生的机制、氧化应激受损的作用，以及引入氧化应激调节剂在乳腺癌治疗策略中的益处。本综述更侧重于我们在过去十年中一直在研究的褪黑素。我们的数据与文献一致，表明褪黑素在乳腺癌的预防和辅助治疗中具有重要作用。
