使用综合指标评估医院中针对主要细菌病原体的抗生素治疗效果。
Assessing antibiotic therapy effectiveness against the major bacterial pathogens in a hospital using an integrated index.
作者信息
Chen Yong, Song Boqiang, Shan Xue, Qin Yanhong, Wang Liang, Wang Hongyuan, Lu Zhongyi, Liu Lin, Yin Danping, Han Xuelin, Zhao Jingya, Tian Shuguang, Chen Fangyan, Su Xueting, Huang Liuyu, Li Qi, Grundmann Hajo, Zhang Hong, Han Li
机构信息
Center for Hospital Infection Control, Institute of Disease Control & Prevention, Academy of Military Medical Sciences, Beijing 100071, China.
School of Earth & Space Sciences (SESS), Peking University, Beijing 100871, China.
出版信息
Future Microbiol. 2017 Aug;12:853-866. doi: 10.2217/fmb-2017-0025. Epub 2017 Jul 12.
AIM
To assess the effectiveness of antibiotic therapy against five indicator bacteria in a Chinese hospital using an index-based approach.
METHODS
The study population comprises 1031 patients who had one clinically significant bacterial isolate in 2008, 2010 and 2013. Drug resistance index (DRI) based on pathogens was calculated.
RESULTS
The adaptive DRIs for Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus decreased, while both adaptive and fixed DRIs for Acinetobacter spp. increased from 2008 to 2013. The adaptive DRIs for Escherichia coli increased from 2008 to 2013, while the fixed DRIs exhibited a decreasing trend.
CONCLUSION
DRI could be used to demonstrate the changes of antimicrobial resistance and prescribing over time as a result of evolutionary processes and governmental regulatory interference.
目的
采用基于指数的方法评估中国一家医院针对五种指示菌的抗生素治疗效果。
方法
研究人群包括2008年、2010年和2013年有一株临床意义重大的细菌分离株的1031名患者。计算基于病原体的耐药指数（DRI）。
结果
2008年至2013年，肺炎克雷伯菌、铜绿假单胞菌、金黄色葡萄球菌的适应性DRI下降，而不动杆菌属的适应性和固定DRI均上升。2008年至2013年，大肠埃希菌的适应性DRI上升，而固定DRI呈下降趋势。
结论
DRI可用于证明由于进化过程和政府监管干预导致的抗菌药物耐药性和处方随时间的变化。
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