Gupta M A, Gupta A K, Haberman H F
J Am Acad Dermatol. 1986 Apr;14(4):633-45. doi: 10.1016/s0190-9622(86)70081-9.
A review of the literature on the use of psychotropic drugs in dermatologic practice--including the antipsychotic, antidepressant, antianxiety, and hypnotic medications, as well as their pharmacologic properties, guidelines for clinical use, and a profile of adverse effects--is presented. After adverse effects and current guidelines for use are taken into consideration, it is suggested that psychotropic drugs be restricted to dermatologic conditions with clearly discernible psychiatric symptoms, for example, psoriasis and major depression, vitiligo resulting in social anxiety, and delusions of parasitosis. The pharmacologic properties of psychotropic drugs, such as the analgesic properties of certain antidepressants, may be of benefit in the treatment of dermatologic symptoms such as intractable pruritus, since pain and pruritus share the same central nervous system pathways. This use of psychotropic drugs remains to be evaluated by well-designed clinical trials.
本文对皮肤科实践中使用精神药物的文献进行了综述，包括抗精神病药、抗抑郁药、抗焦虑药和催眠药，以及它们的药理特性、临床使用指南和不良反应概况。在考虑不良反应和当前使用指南后，建议将精神药物限制用于具有明显可辨精神症状的皮肤病，例如银屑病伴重度抑郁、导致社交焦虑的白癜风以及寄生虫妄想症。精神药物的药理特性，如某些抗抑郁药的镇痛特性，可能有助于治疗顽固性瘙痒等皮肤症状，因为疼痛和瘙痒共享相同的中枢神经系统通路。精神药物的这种用途仍有待精心设计的临床试验进行评估。
