Deng Kunxue, Yang Yaya, Ke Yiquan, Luo Chengyi, Liu Man, Deng Yuting, Tian Quan, Yuan Yuyu, Yuan Tun, Xu Tao
a Department of Mechanical Engineering and Biomedical Engineering Program , University of Texas at El Paso , El Paso , TX , USA.
b Department of Mechanical Engineering , Bio-manufacturing Center, Tsinghua University , Beijing , China.
Neurol Res. 2017 Sep;39(9):819-829. doi: 10.1080/01616412.2017.1348680. Epub 2017 Jul 12.
Biomimetic design will significantly improve growth and regeneration of dural cells and tissue for better repairing effects and fewer complications in repairing the native dura. This study designed a novel composite, biomimetic substitute based on the characteristics of native dura extracellular matrix.
This substitute is expected to rapidly induce cell adhesion, migration, and fast regeneration of neotissue. The material characteristics (contact angle, surface charge, and zeta potential were evaluated), in vitro biological characteristics (cell stretch, connections between cells, cell proliferation) and in vivo tissue regeneration capability of this substitute were evaluated, compared to those of collagen dura substitute, the mostly used dura substitute. The results showed that the surface properties of this composite substitute were more biomimetic to native extracellular matrix than collagen substitute did, together with better cytocompatibility, tissue ingrowth, and neoangiogenesis. This composite substitute further demonstrated in clinical case study its ideal repair effect with no CSF leakage or other adverse reactions.
In conclusion, the new biomimetic composite substitute provides alternative substitute for dura repairing.
仿生设计将显著促进硬脑膜细胞和组织的生长与再生，从而在修复天然硬脑膜时获得更好的修复效果并减少并发症。本研究基于天然硬脑膜细胞外基质的特性设计了一种新型的复合仿生替代物。
该替代物有望快速诱导细胞黏附、迁移并促进新组织的快速再生。评估了该替代物的材料特性（接触角、表面电荷和zeta电位）、体外生物学特性（细胞伸展、细胞间连接、细胞增殖）以及体内组织再生能力，并与最常用的硬脑膜替代物胶原硬脑膜替代物进行了比较。结果表明，与胶原替代物相比，这种复合替代物的表面特性更接近天然细胞外基质，同时具有更好的细胞相容性、组织长入和新生血管形成能力。该复合替代物在临床病例研究中进一步证明了其理想的修复效果，无脑脊液漏或其他不良反应。
总之，新型仿生复合替代物为硬脑膜修复提供了替代选择。
