Khurana Dolphee, Suresh Ankitha, Nayak Raghavendra, Shetty Manjunath, Sarda Rohit Kumar, Knowles Jonathan C, Kim Hae-Won, Singh Rajendra K, Singh Bhisham Narayan
Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Department of Neurosurgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
J Tissue Eng. 2024 Feb 9;15:20417314241228118. doi: 10.1177/20417314241228118. eCollection 2024 Jan-Dec.
The dura mater, as the crucial outermost protective layer of the meninges, plays a vital role in safeguarding the underlying brain tissue. Neurosurgeons face significant challenges in dealing with trauma or large defects in the dura mater, as they must address the potential complications, such as wound infections, pseudomeningocele formation, cerebrospinal fluid leakage, and cerebral herniation. Therefore, the development of dural substitutes for repairing or reconstructing the damaged dura mater holds clinical significance. In this review we highlight the progress in the development of dural substitutes, encompassing autologous, allogeneic, and xenogeneic replacements, as well as the polymeric-based dural substitutes fabricated through various scaffolding techniques. In particular, we explore the development of composite materials that exhibit improved physical and biological properties for advanced dural substitutes. Furthermore, we address the challenges and prospects associated with developing clinically relevant alternatives to the dura mater.
硬脑膜作为脑膜至关重要的最外层保护层，在保护其下方的脑组织方面发挥着关键作用。神经外科医生在处理硬脑膜创伤或大的缺损时面临重大挑战，因为他们必须应对潜在的并发症，如伤口感染、假性脑膜膨出形成、脑脊液漏和脑疝。因此，开发用于修复或重建受损硬脑膜的硬脑膜替代物具有临床意义。在本综述中，我们重点介绍了硬脑膜替代物的发展进展，包括自体、异体和异种替代物，以及通过各种支架技术制造的基于聚合物的硬脑膜替代物。特别是，我们探讨了具有改善的物理和生物学特性以用于先进硬脑膜替代物的复合材料的发展。此外，我们还讨论了开发与硬脑膜临床相关替代物所面临的挑战和前景。
