鲁索替尼被发现可导致睫毛生长：一例报告。
Ruxolitinib found to cause eyelash growth: a case report.
作者信息
Song Julia, Song Alice, Palmares Trisa, Song Michael, Song Harold
机构信息
Southern California Eye Physicians & Surgeons, 800 S. Fairmount Ave., #207, Pasadena, CA, 91105, USA.
Center for Oculofacial & Orbital Surgery, 3771 Katella Ave., #209, Los Alamitos, CA, 90720, USA.
出版信息
J Med Case Rep. 2017 Jul 12;11(1):189. doi: 10.1186/s13256-017-1304-5.
BACKGROUND
Hypereosinophilic syndrome is a hematologic disorder in which the eosinophils proliferate. Oral Janus kinase inhibitors are known to be effective treating hypereosinophilic syndrome. Janus kinase inhibitors have also demonstrated efficacy in alopecia. Madarosis is a condition in which the eyelashes are missing or absent and can been seen in alopecia patients.
CASE PRESENTATION
We present the case of a 77-year-old Asian man who was diagnosed with hypereosinophilic syndrome, refractive to all medications except ruxolitinib. He responded well. It was noted unexpectedly that his eyelashes grew much longer than they were normally.
CONCLUSIONS
Previous studies have demonstrated an improvement in alopecia areata, with increased hair growth on the head and eyebrows. This study demonstrates that longer eyelashes may be another effect of oral Janus kinase inhibitors. We report the first case of eyelash elongation and thickening in a patient taking ruxolitinib. Physicians and patients should be aware of the side effect of these Janus kinase inhibitors. Further investigation is needed to ascertain whether ruxolitinib or other interleukin inhibitors can aid in the treatment of madarosis.
背景
嗜酸性粒细胞增多综合征是一种嗜酸性粒细胞增殖的血液系统疾病。口服Janus激酶抑制剂已知对治疗嗜酸性粒细胞增多综合征有效。Janus激酶抑制剂在脱发治疗中也已显示出疗效。睫毛脱落症是一种睫毛缺失或没有睫毛的病症，可在脱发患者中见到。
病例报告
我们报告一例77岁亚洲男性患者，被诊断为嗜酸性粒细胞增多综合征，除芦可替尼外对所有药物均耐药。他对芦可替尼反应良好。意外的是，发现他的睫毛比正常情况下长得长得多。
结论
先前的研究表明斑秃有所改善，头部和眉毛处的毛发生长增加。本研究表明睫毛变长可能是口服Janus激酶抑制剂的另一个作用。我们报告了首例服用芦可替尼的患者出现睫毛变长变浓密的情况。医生和患者应意识到这些Janus激酶抑制剂的副作用。需要进一步研究以确定芦可替尼或其他白细胞介素抑制剂是否有助于治疗睫毛脱落症。
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