聚乙二醇分子量对扑热息痛-聚乙二醇固体分散体生物利用度的影响。
The effect of the molecular weight of polyethylene glycol on the bioavailability of paracetamol-polyethylene glycol solid dispersions.
作者信息
Vila-Jato J L, Blanco J, Alonso M J
出版信息
J Pharm Pharmacol. 1986 Feb;38(2):126-8. doi: 10.1111/j.2042-7158.1986.tb04525.x.
Abstract
A controlled study of the bioavailability of paracetamol in solid dispersion with PEG 6000, 10000 and 20000 has been made. The total amount of paracetamol excreted in urine increased with molecular weight of the PEG, but the rate of absorption of the drug was unaffected.
摘要
已对扑热息痛与聚乙二醇6000、10000和20000形成的固体分散体的生物利用度进行了对照研究。尿中排泄的扑热息痛总量随聚乙二醇分子量的增加而增加，但药物的吸收速率未受影响。
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