一项关于疼痛相关恐惧的全基因组关联初步研究：对口面部疼痛的启示
A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain.
作者信息
Randall Cameron L, Wright Casey D, Chernus Jonathan M, McNeil Daniel W, Feingold Eleanor, Crout Richard J, Neiswanger Katherine, Weyant Robert J, Shaffer John R, Marazita Mary L
机构信息
Department of Psychology, West Virginia University, 53 Campus Drive, P.O. Box 6040, Morgantown, WV 26506, USA.
Department of Dental Practice & Rural Health, Center for Oral Health Research in Appalachia (COHRA), School of Dentistry, West Virginia University, One Medical Center Drive, Morgantown, WV 26506, USA.
出版信息
Pain Res Manag. 2017;2017:7375468. doi: 10.1155/2017/7375468. Epub 2017 Jun 15.
BACKGROUND
Acute and chronic orofacial pain can significantly impact overall health and functioning. Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated. Little is known, however, regarding the specific genes contributing to fear of pain.
METHODS
A genome-wide association study (GWAS; = 990) was performed to identify plausible genes that may predispose individuals to various levels of fear of pain. The total score and three subscales (fear of minor, severe, and medical/dental pain) of the Fear of Pain Questionnaire-9 (FPQ-9) were modeled in a variance components modeling framework to test for genetic association with 8.5 M genetic variants across the genome, while adjusting for sex, age, education, and income.
RESULTS
Three genetic loci were significantly associated with fear of minor pain (8q24.13, 8p21.2, and 6q26; < 5 × 10 for all) near the genes , , , , and . Other suggestive loci were found for the fear of pain total score and each of the FPQ-9 subscales.
CONCLUSIONS
Multiple genes were identified as possible candidates contributing to fear of pain. The findings may have implications for understanding and treating chronic orofacial pain.
背景
急慢性口面部疼痛会对整体健康和功能产生重大影响。疼痛恐惧与口面部疼痛体验之间的关联已有充分记录，且疼痛恐惧的环境、行为和认知成分也已阐明。然而，对于导致疼痛恐惧的具体基因却知之甚少。
方法
进行了一项全基因组关联研究（GWAS；n = 990），以确定可能使个体易患不同程度疼痛恐惧的合理基因。在方差成分建模框架中，对疼痛恐惧问卷-9（FPQ-9）的总分及三个子量表（轻微疼痛恐惧、严重疼痛恐惧和医疗/牙科疼痛恐惧）进行建模，以测试与全基因组850万个遗传变异的基因关联，同时对性别、年龄、教育程度和收入进行校正。
结果
三个基因位点与轻微疼痛恐惧显著相关（8q24.13、8p21.2和6q26；所有P值均<5×10⁻⁸），分别靠近基因[具体基因未给出]、[具体基因未给出]、[具体基因未给出]、[具体基因未给出]和[具体基因未给出]。还发现了其他一些与疼痛恐惧总分及FPQ-9各子量表相关的提示性位点。
结论
多个基因被确定为可能导致疼痛恐惧的候选基因。这些发现可能对理解和治疗慢性口面部疼痛具有重要意义。
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