使用体重指数预测残胃癌患者的预后。
Use of Body Mass Index to Predict the Prognosis of Patients with Remnant Gastric Cancer.
作者信息
Matsunaga Tomoyuki, Saito Hiroaki, Osaki Tomohiro, Kono Yusuke, Murakami Yuki, Kuroda Hirohiko, Fukumoto Yoji, Fujiwara Yoshiyuki
机构信息
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan.
出版信息
Yonago Acta Med. 2017 Jun 26;60(2):126-132. eCollection 2017 Jun.
BACKGROUND
Remnant gastric cancer (RGC) is an uncommon form of gastric cancer. The aim of this study was to investigate factors influencing the prognosis of patients with RGC.
METHODS
A total of 49 patients diagnosed with RGC and 214 patients with primary upper third gastric cancer (PUGC) at our institution between January 1990 and December 2014 were included. The clinicopathological characteristics, prognosis, and factors influencing prognosis were compared.
RESULTS
The body mass index (BMI) of RGC was significantly lower than that for PUGC ( < 0.0001). Multivariate analysis revealed that BMI and the depth of tumor invasion were independent prognostic factors in RGC. ROC analysis indicated that an optimal cut-off value for BMI was 20.6. Based on this value, patients were divided into two groups: BMI (≥ 20.6) and BMI (< 20.6). The 5-year survival rates of patients with BMI early gastric cancer, BMI advanced gastric cancer, BMI early gastric cancer, and BMI advanced gastric cancer were 90%, 83.3%, 64.3% and 33.8%, respectively, and the difference was statistically significant ( = 0.00023).
CONCLUSION
Our retrospective study indicated a poor prognosis of RGC compared with PUGC, and that BMI could predict the prognosis of RGC. The prognosis of patients with BMI advanced RGC was extremely poor.
背景
残胃癌（RGC）是一种罕见的胃癌形式。本研究的目的是探讨影响残胃癌患者预后的因素。
方法
纳入1990年1月至2014年12月在本机构诊断为残胃癌的49例患者和214例原发性胃上部癌（PUGC）患者。比较其临床病理特征、预后及影响预后的因素。
结果
残胃癌患者的体重指数（BMI）显著低于原发性胃上部癌患者（<0.0001）。多因素分析显示，BMI和肿瘤浸润深度是残胃癌的独立预后因素。ROC分析表明，BMI的最佳截断值为20.6。基于该值，患者被分为两组：BMI（≥20.6）组和BMI（<20.6）组。BMI早期胃癌、BMI进展期胃癌、BMI早期胃癌和BMI进展期胃癌患者的5年生存率分别为90%、83.3%、64.3%和33.8%，差异有统计学意义（=0.00023）。
结论
我们的回顾性研究表明，与原发性胃上部癌相比，残胃癌的预后较差，且BMI可预测残胃癌的预后。BMI进展期残胃癌患者的预后极差。
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