Wilkins Alastair
MS and Stem Cell Group, University of Bristol, Learning and Research, Southmead Hospital, Bristol, United Kingdom.
Front Neurol. 2017 Jun 28;8:312. doi: 10.3389/fneur.2017.00312. eCollection 2017.
Multiple sclerosis (MS) commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs contribute significantly to clinical disability, and symptoms such as tremor, ataxia, and dysarthria are particularly difficult to treat. Increasing knowledge concerning the pathophysiology of cerebellar disease in MS from human postmortem studies, experimental models, and clinical trials has raised the hope that cerebellar symptoms will be better treated in the future.
多发性硬化症(MS)通常会影响小脑,导致急性和慢性症状。小脑体征对临床残疾有显著影响,而震颤、共济失调和构音障碍等症状尤其难以治疗。来自人体尸检研究、实验模型和临床试验的关于MS中小脑疾病病理生理学的知识不断增加,这让人们燃起了未来能更好治疗小脑症状的希望。