University of North Carolina, 1101-B McGavran-Greenberg Bldg., 135 Dauer Dr., CB-7411, Chapel Hill, NC, 27599-7411, USA.
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Breast Cancer Res Treat. 2017 Nov;166(1):207-215. doi: 10.1007/s10549-017-4386-2. Epub 2017 Jul 12.
Younger women (aged 18-44 years) diagnosed with breast cancer often face more aggressive tumors, higher treatment intensity, and lower survival rates than older women. In this study, we estimated incident breast cancer costs by stage at diagnosis and by race for younger women enrolled in Medicaid.
We analyzed cancer registry data linked to Medicaid claims in North Carolina from 2003 to 2008. We used Surveillance, Epidemiology, and End Results (SEER) Summary 2000 definitions for cancer stage. We split breast cancer patients into two cohorts: a younger and older group aged 18-44 and 45-64 years, respectively. We conducted a many-to-one match between patients with and without breast cancer using age, county, race, and Charlson Comorbidity Index. We calculated mean excess total cost of care between breast cancer and non-breast cancer patients.
At diagnosis, younger women had a higher proportion of regional cancers than older women (49 vs. 42%) and lower proportions of localized cancers (44 vs. 50%) and distant cancers (7 vs. 9%). The excess costs of breast cancer (all stages) for younger and older women at 6 months after diagnosis were $37,114 [95% confidence interval (CI) = $35,769-38,459] and $28,026 (95% CI = $27,223-28,829), respectively. In the 6 months after diagnosis, the estimated excess cost was significantly higher to treat localized and regional cancer among younger women than among older women. There were no statistically significant differences in excess costs of breast cancer by race, but differences in treatment modality were present among younger Medicaid beneficiaries.
Younger breast cancer patients not only had a higher prevalence of late-stage cancer than older women, but also had higher within-stage excess costs.
年轻女性(年龄在 18-44 岁之间)诊断出患有乳腺癌时,其肿瘤往往更具侵袭性,治疗强度更高,生存率也低于年长女性。本研究旨在评估在北卡罗来纳州参加医疗补助计划的年轻女性中,按诊断时的肿瘤分期和种族来估算乳腺癌的发病成本。
我们分析了 2003 年至 2008 年北卡罗来纳州癌症登记处与医疗补助索赔相关的数据。我们使用癌症分期的监测、流行病学和最终结果(SEER)总结 2000 年定义。我们将乳腺癌患者分为两个队列:年龄分别为 18-44 岁和 45-64 岁的年轻组和年长组。我们采用年龄、县、种族和 Charlson 合并症指数,对患有和未患有乳腺癌的患者进行多对一匹配。我们计算了乳腺癌和非乳腺癌患者之间的总护理费用的平均超额。
在诊断时,年轻女性的区域性癌症比例高于年长女性(49%比 42%),而局限性癌症(44%比 50%)和远处癌症(7%比 9%)的比例较低。诊断后 6 个月时,年轻和年长女性所有分期乳腺癌的超额成本分别为 37114 美元(95%置信区间[CI]:35769-38459 美元)和 28026 美元(95% CI:27223-28829 美元)。诊断后 6 个月时,年轻女性治疗局限性和区域性癌症的超额成本明显高于年长女性。不同种族间乳腺癌的超额成本没有统计学上的显著差异,但年轻医疗补助受益人的治疗方式存在差异。
年轻乳腺癌患者不仅比年长女性更常见晚期癌症,而且其同阶段的超额成本也更高。