Department of Dermatology, University of Rome “G. Marconi”, Rome, Italy.
Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
J Biol Regul Homeost Agents. 2017;31(2 Suppl. 2):107-120.
To retrieve the history of venous ulcers and of skin lesions in general, we must go back to the appearance of human beings on earth. It is interesting to note that cutaneous injuries evolved parallel to human society. An essential first step in the pathogenesis of ulcers was represented by the transition of the quadruped man to Homo Erectus. This condition was characterized by a greater gravitational pressure on the lower limbs, with consequences on the peripheral venous system. Furthermore, human evolution was characterized by an increased risk of traumatic injuries, secondary to his natural need to create fire and hunt (e.g. stones, iron, fire, animal fighting). Humans then began to fight one another until they came to real wars, with increased frequency of wounds and infectious complications. The situation degraded with the introduction of horse riding, introduced by the Scites, who first tamed animals in the 7th century BC. This condition exhibited iliac veins at compression phenomena, favouring the venous stasis. With time, man continued to evolve until the modern age, which is characterized by increased risk factors for venous wounds such as poor physical activity and dietary errors (1, 2).
为了追溯静脉溃疡和一般皮肤损伤的历史，我们必须追溯到人类在地球上的出现。有趣的是，皮肤损伤与人类社会平行发展。溃疡发病机制中的一个重要第一步是四足人类向直立人(Homo Erectus)的转变。这种情况的特点是下肢承受更大的重力压力，对周围静脉系统产生影响。此外，人类进化的特点是由于他创造火和狩猎的自然需要而导致创伤性损伤的风险增加（例如，石头、铁、火、动物搏斗）。人类开始相互争斗，直到真正的战争爆发，伤口和感染性并发症的频率增加。随着斯基泰人（Scites）在公元前 7 世纪首次驯服动物而引入骑马，情况恶化了。这种情况表现出髂静脉受压现象，有利于静脉淤滞。随着时间的推移，人类继续进化，直到现代，现代的特点是静脉伤口的危险因素增加，如身体活动不足和饮食错误（1,2）。
