Kuzmanović Elabjer B, Bušić M, Miletić D, Bjeloš M, Vukojević N, Bosnar D
a University Eye Clinic, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, University Hospital "Sveti Duh" , Zagreb , Croatia.
b University Eye Clinic, University Hospital Centre Zagreb , Zagreb , Croatia.
Semin Ophthalmol. 2018;33(4):571-575. doi: 10.1080/08820538.2017.1346131. Epub 2017 Jul 13.
To evaluate, by ultrasound biomicroscopy (UBM), changes in scleral thickness after ruthenium-106 CCB and CCC plaque (Eckert & Ziegler BE-BIG GmbH, Berlin, Germany) therapy for anterior ciliary melanoma.
Eleven patients with anterior ciliary melanoma underwent ruthenium-106 CCB and CCC plaque radiation with a radiation dose at the tumor apex of 80-100 Gy. UBM measurements performed prior to and after treatment were as follows: the largest prominence of the tumor perpendicular to the sclera and scleral thickness at scleral spur, 1.0 mm, and 2.0 mm posteriorly.
The article presents one year follow-up results for each of the 11 patients. The mean regression of the tumor of 24.3±9.31% was observed. The thinning of the sclera was statistically significant at the scleral spur (t=1.80, p ≤ 0.05) and at maximal tumor thickness (t=1.35, P=0.05).
UBM documented significant thinning of the sclera at the scleral spur and overlying the maximal tumor thickness after Ru-106 CCB and CCC plaque radiation. Taking into consideration the shortcomings of the study-small sample size, insufficient probe resolution, and subjectively determined anatomic landmarks-observed minimal thickness change of the sclera does not necessarily mean its necrosis. However, thinning of the sclera documented at one year follow-up associated with very slow regression of the tumor indicates the need for the introduction of the CIA plaque treatment in our patients with anterior ciliary melanoma.
通过超声生物显微镜（UBM）评估钌 - 106 巩膜敷贴器和巩膜外敷贴器（Eckert & Ziegler BE - BIG GmbH，柏林，德国）治疗睫状体前黑色素瘤后巩膜厚度的变化。
11 例睫状体前黑色素瘤患者接受了钌 - 106 巩膜敷贴器和巩膜外敷贴器放射治疗，肿瘤顶点的放射剂量为 80 - 100 Gy。治疗前后进行的 UBM 测量如下：肿瘤垂直于巩膜的最大隆起处以及在巩膜突、巩膜突后 1.0 mm 和 2.0 mm 处的巩膜厚度。
本文呈现了 11 例患者中每例患者的一年随访结果。观察到肿瘤平均消退 24.3±9.31%。巩膜在巩膜突处（t = 1.80，p≤0.05）和肿瘤最大厚度处（t = 1.35，P = 0.05）变薄具有统计学意义。
UBM 记录了钌 - 106 巩膜敷贴器和巩膜外敷贴器放射治疗后巩膜突处及覆盖肿瘤最大厚度处的巩膜显著变薄。考虑到该研究的缺点——样本量小、探头分辨率不足以及解剖标志主观确定——观察到的巩膜最小厚度变化不一定意味着其坏死。然而，一年随访中记录的巩膜变薄与肿瘤非常缓慢的消退相关，这表明在我们的睫状体前黑色素瘤患者中需要引入 CIA 敷贴器治疗。
