Choo Min Soo, Choi Se Rin, Han Jun Hyun, Lee Seong Ho, Shim Young Suk
Department of Urology, Hallym University Medical Center, Hallym University College of Medicine, Chuncheon, Seoul, Korea.
Department of Pediatrics, Hallym University Medical Center, Hallym University College of Medicine, Chuncheon, Seoul, Korea.
PLoS One. 2017 Jul 13;12(7):e0177311. doi: 10.1371/journal.pone.0177311. eCollection 2017.
This study aimed to evaluate the relationship between insulin resistance and the bone mineral density (BMD) of femur and lumbar spine in Korean adults who are expected to exhibit near peak bone mass.
Data from the Korean National Health and Nutrition Examination Survey 2008-2010 were analyzed. A total of 2,750 participants aged 25-35 years were included. Insulin resistance was assessed using a homeostatic model assessment of insulin resistance (HOMA-IR) and serum fasting insulin.
In a multivariate linear regression analysis, the HOMA-IR was significantly inversely associated with the BMD of the total hip (TH, β = -0.052, P = 0.002), femoral neck (FN, β = -0.072, P<0.001), femoral trochanter (FTr, β = -0.055, P = 0.003), femoral intertrochanter (FITr, β = -0.041, P = 0.015), and lumbar spine (LS, β = -0.063, P = 0.001) among all study subjects after adjustment for gender, age, height, weight, whole body fat mass percentage, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, vitamin D, smoking, alcohol intake, physical activity, education level, and household income in both genders as well as labor, the use of oral contraceptives, and age at menarche in females. The serum fasting insulin was significantly inversely associated with the BMD of the TH (β = -0.055, P = 0.001), FN (β = -0.072, P<0.001), FTr (β = -0.055, P = 0.003), FITr (β = -0.045, P = 0.009), and LS (β = -0.064, P = 0.001) among all subjects in a multivariate linear regression analysis.
Our results suggest that insulin resistance may be independently and inversely associated with the near peak bone mass of the femur and lumbar spine.
本研究旨在评估在预计骨量接近峰值的韩国成年人中，胰岛素抵抗与股骨和腰椎骨密度（BMD）之间的关系。
分析了2008 - 2010年韩国国家健康与营养检查调查的数据。共纳入2750名年龄在25 - 35岁的参与者。使用胰岛素抵抗稳态模型评估（HOMA - IR）和血清空腹胰岛素来评估胰岛素抵抗。
在多因素线性回归分析中，在校正了性别、年龄、身高、体重、全身脂肪质量百分比、收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、维生素D、吸烟、饮酒、身体活动、教育水平、家庭收入（包括男性的劳动情况、女性口服避孕药的使用情况和初潮年龄）后，HOMA - IR与所有研究对象的全髋（TH，β = -0.052，P = 0.002）、股骨颈（FN，β = -0.072，P<0.001）、股骨大转子（FTr，β = -0.055，P = 0.003）、股骨转子间（FITr，β = -0.041，P = 0.015）和腰椎（LS，β = -0.063，P = 0.001）的骨密度显著负相关。在多因素线性回归分析中，血清空腹胰岛素与所有研究对象的TH（β = -0.055，P = 0.001）、FN（β = -0.072，P<0.001）、FTr（β = -0.055，P = 0.003）、FITr（β = -0.045，P = 0.009）和LS（β = -0.064，P = 0.001）的骨密度显著负相关。
我们的结果表明，胰岛素抵抗可能与股骨和腰椎接近峰值的骨量独立且呈负相关。
