Park S-W, Nam G-E, Jung D-W, Yoon S-J, Han K, Park Y-G, Choi J-S, Lee J-E, Sang J-E, Yoon Y-J, Kim D-H
Department of Family Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, 516 Gojan-dong, Danwon-gu, Ansan-si, Gyeonggi-do, 425-707, South Korea.
Department of Biostatistics, Catholic University College of Medicine, Seoul, 137-701, South Korea.
Osteoporos Int. 2016 Feb;27(2):635-42. doi: 10.1007/s00198-015-3306-8. Epub 2015 Sep 2.
This study investigated the association between lipid profiles and insulin resistance and bone mineral content (BMC) in Korean adolescents and found that BMC was inversely associated with triglyceride (TG) and homeostasis model assessment of insulin resistance (HOMA-IR). This association did not differ according to obesity status in either boys or girls.
To prevent future osteoporosis, it is important to identify factors that affect bone health in adolescents as well as adults. This study aimed to examine the association between lipid profiles and insulin resistance and BMC in Korean adolescents.
Data from 706 boys and 621 girls, who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2011, were analyzed. Lipid profiles were measured, and HOMA-IR was calculated to assess insulin resistance. BMC was measured for the total femur, femur neck, and lumbar spine by using whole-body dual-energy X-ray absorptiometry (DXA).
TG level and HOMA-IR were negatively correlated with BMC at all three sites in boys. In girls, TG level showed a negative correlation with BMC at the femur neck and lumbar spine, and HOMA-IR was negatively associated with BMC at the femur neck only. These inverse associations did not differ according to obesity status in either sex. Adjusted means of BMC at the three sites in boys tended to decrease in the higher tertile groups of TG and HOMA-IR, and the adjusted means of BMC for the total femur in girls tended to decrease in the higher tertile groups of TG and HOMA-IR.
BMC was inversely associated with TG and HOMA-IR in Korean adolescents, and this association was more pronounced in boys. This association did not differ according to obesity status in either sex.
本研究调查了韩国青少年血脂水平与胰岛素抵抗及骨矿物质含量（BMC）之间的关联，发现BMC与甘油三酯（TG）及胰岛素抵抗稳态模型评估（HOMA-IR）呈负相关。无论男孩还是女孩，这种关联在肥胖状态方面并无差异。
为预防未来的骨质疏松症，识别影响青少年及成年人骨骼健康的因素非常重要。本研究旨在探讨韩国青少年血脂水平与胰岛素抵抗及BMC之间的关联。
分析了2008年至2011年参加韩国国家健康与营养检查调查的706名男孩和621名女孩的数据。测量了血脂水平，并计算HOMA-IR以评估胰岛素抵抗。通过全身双能X线吸收法（DXA）测量了股骨、股骨颈和腰椎的BMC。
在男孩中，TG水平和HOMA-IR与所有三个部位的BMC均呈负相关。在女孩中，TG水平与股骨颈和腰椎的BMC呈负相关，而HOMA-IR仅与股骨颈的BMC呈负相关。无论男女，这些负相关在肥胖状态方面并无差异。男孩三个部位BMC的调整均值在TG和HOMA-IR较高三分位数组中趋于下降，女孩股骨总BMC的调整均值在TG和HOMA-IR较高三分位数组中趋于下降。
韩国青少年的BMC与TG和HOMA-IR呈负相关，且这种关联在男孩中更为明显。无论男女，这种关联在肥胖状态方面并无差异。
