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哇巴因对家兔嗅球细胞外天冬氨酸、谷氨酸和γ-氨基丁酸水平的影响（体内实验）

Ouabain-induced changes in extracellular aspartate, glutamate and GABA levels in the rabbit olfactory bulb in vivo.

作者信息

Jacobson I, Hagberg H, Sandberg M, Hamberger A

出版信息

Neurosci Lett. 1986 Feb 28;64(2):211-5. doi: 10.1016/0304-3940(86)90102-3.

DOI:10.1016/0304-3940(86)90102-3
PMID:2870447
Abstract

The effect of ouabain on extracellular amino acid levels was investigated in the rabbit olfactory bulb using brain dialysis. Extracellular field potentials, elicited by stimulation of the lateral olfactory tract (LOT), were recorded simultaneously. Ouabain (100 microM) induced a rapid increase in extracellular aspartate, glutamate and gamma-aminobutyric acid. LOT-evoked potentials changed concomitantly, suggesting a neuronal depolarization.

摘要

使用脑透析技术在兔嗅球中研究了哇巴因对细胞外氨基酸水平的影响。同时记录了刺激外侧嗅束（LOT）诱发的细胞外场电位。哇巴因（100微摩尔）引起细胞外天冬氨酸、谷氨酸和γ-氨基丁酸迅速增加。LOT诱发的电位也随之改变，提示神经元去极化。

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