白藜芦醇可改善慢性前列腺炎患者前列腺功能障碍进展过程中的前列腺纤维化。
Resveratrol improves prostate fibrosis during progression of urinary dysfunction in chronic prostatitis.
机构信息
Department of Urology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
出版信息
Environ Toxicol Pharmacol. 2017 Sep;54:120-124. doi: 10.1016/j.etap.2017.06.025. Epub 2017 Jul 1.
AIM
We investigated whether prostate fibrosis was associated with urinary dysfunction in chronic prostatitis (CP) and whether resveratrol improved urinary dysfunction and the underlying molecular mechanism.
METHODS
Rat model of CP was established via subcutaneous injections of DPT vaccine and subsequently treated with resveratrol. Bladder pressure and volume tests investigated the effect of resveratrol on urinary dysfunction in CP rats. Western blotting and immunohistochemical staining examined the expression level of C-kit/SCF and TGF-β/Wnt/β-catenin.
RESULTS
Compared to the control group, the maximum capacity of the bladder, residual urine volume and maximum voiding pressure, the activity of C-kit/SCF and TGF-β/Wnt/β-catenin pathways were increased significantly in the CP group. Resveratrol treatment significantly improved these factors.
CONCLUSION
CP induced significantly prostate fibrosis, which exhibits a close relationship with urinary dysfunction. Resveratrol improved fibrosis, which may be associated with the suppression of C-kit/SCF and TGF-β/Wnt/β-catenin pathway.
目的
研究前列腺纤维化是否与慢性前列腺炎（CP）中的尿路功能障碍有关，以及白藜芦醇是否能改善尿路功能障碍及其潜在的分子机制。
方法
通过皮下注射 DPT 疫苗建立 CP 大鼠模型，随后用白藜芦醇进行治疗。膀胱压力和容量测试研究了白藜芦醇对 CP 大鼠尿路功能障碍的影响。Western blot 和免疫组织化学染色检测了 C-kit/SCF 和 TGF-β/Wnt/β-catenin 表达水平。
结果
与对照组相比，CP 组膀胱最大容量、残余尿量和最大排尿压、C-kit/SCF 和 TGF-β/Wnt/β-catenin 通路活性显著升高。白藜芦醇治疗后这些因子明显改善。
结论
CP 可引起明显的前列腺纤维化，其与尿路功能障碍密切相关。白藜芦醇改善纤维化可能与抑制 C-kit/SCF 和 TGF-β/Wnt/β-catenin 通路有关。
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