Chen Danyan, Huang Xiaolong, Lu Song, Deng Huacong, Gan Hua, Du Xiaogang, Weixue Tang
Departments of Endocrinology & Nephrology, the Chongqing General Hospital, Chongqing, China.
Departments of Neurosurgery, No. 324 Hospital of PLA, Chongqing, China.
Exp Clin Endocrinol Diabetes. 2017 Sep;125(8):547-553. doi: 10.1055/s-0043-109099. Epub 2017 Jul 13.
To investigate the RBP4/Lp-PLA/Netrin-1 signal regulation of cognitive function impairment in diabetic nephropathy patients with silent cerebral infarction (SCI). One-hundred patients newly diagnosed with diabetic nephropathy patients were included. The patients were divided into SCI group and NSCI group according to the radiological data. The degrees of cognitive dysfunction were evaluated. Serum RBP4 concentrations were determined by ELISA and protein expressions of Lp-PLA and Netrin-1 were determined by Western Blot. Compared with NSCI group, the cognitive function of patients in SCI group was impaired, the concentrations of RBP4 and the expressions of Lp-PLA and Netrin-1 increased (P<0.05). RBP4 concentrations were positively correlated with the cognitive dysfunction of SCI patients. Moreover, there existed a regression correlation between them. RBP4 may be used as a predictive factor of diabetic nephropathy patients complicated with SCI and is positively correlated with cognitive dysfunction. RBP4/Lp-PLA/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI.
探讨视黄醇结合蛋白4（RBP4）/脂蛋白相关磷脂酶A（Lp-PLA）/轴突导向因子1（Netrin-1）信号对糖尿病肾病合并无症状脑梗死（SCI）患者认知功能损害的调控作用。纳入100例新诊断的糖尿病肾病患者。根据影像学资料将患者分为SCI组和非SCI组。评估认知功能障碍程度。采用酶联免疫吸附测定（ELISA）法测定血清RBP4浓度，采用蛋白质印迹法测定Lp-PLA和Netrin-1的蛋白表达。与非SCI组相比，SCI组患者认知功能受损，RBP4浓度、Lp-PLA和Netrin-1表达升高（P<0.05）。RBP4浓度与SCI患者认知功能障碍呈正相关。此外，二者之间存在回归相关性。RBP4可作为糖尿病肾病合并SCI患者的预测因子，且与认知功能障碍呈正相关。RBP4/Lp-PLA/Netrin-1信号通路激活可能是糖尿病肾病合并SCI的发病机制之一。
