Shusterman M, Golub E, Mowrey W B, Broder A
1 Department of Medicine, Montefiore Medical Center, New York, USA.
2 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, USA.
Lupus. 2018 Feb;27(2):319-326. doi: 10.1177/0961203317721352. Epub 2017 Jul 14.
Objectives Although non-O blood type is an established risk factor for venous thromboembolism in the general population, the impact of ABO blood type (ABO) on venous thromboembolism risk in individuals with persistent antiphospholipid antibodies (aPL) has not been studied. We sought to investigate the relationship between ABO and venous thromboembolism in aPL-positive individuals. We also sought to explore potential interactions between ABO and sex or race to determine whether ABO contributes to race or sex differences with respect to the development of venous thromboembolism. Methods We identified all patients over 18 years old followed at a tertiary medical center between January 2000 and January 2015 with serological aPL criteria and ABO data. Episodes of venous thromboembolism were recorded. Logistic regression models were fitted to estimate odds ratios (ORs) of venous thromboembolism for non-O (A, B, or AB blood types) versus O blood type. Results There were 226 patients included in the final analysis, of whom 75 (33%) had reported venous thromboembolism. In the overall sample, there was a non-significant difference between venous thromboembolism in patients with non-O blood type compared to O blood type (OR 1.64, 95% confidence interval (CI) 0.94, 2.88; P = 0.08). Men with non-O blood type had a significantly higher risk of venous thromboembolism as compared to men with O-type blood (OR 4.94, 95% CI 1.37, 17.85; P = 0.02), but there was no significant association between ABO and venous thromboembolism among women (OR 0.96, 95% CI 0.50, 1.83; P = 0.52). Conclusions Non-O blood type may be an under-recognized risk factor for venous thromboembolism among men with persistent aPL antibodies, whereas the risk associated with non-O blood type seen in the general population may be attenuated in aPL-positive women.
目的 虽然非O血型是一般人群静脉血栓栓塞的既定风险因素，但ABO血型对持续性抗磷脂抗体（aPL）个体静脉血栓栓塞风险的影响尚未得到研究。我们试图调查ABO血型与aPL阳性个体静脉血栓栓塞之间的关系。我们还试图探索ABO血型与性别或种族之间的潜在相互作用，以确定ABO血型是否在静脉血栓栓塞的发生方面导致种族或性别差异。方法 我们确定了2000年1月至2015年1月在一家三级医疗中心随访的所有18岁以上符合血清学aPL标准且有ABO血型数据的患者。记录静脉血栓栓塞事件。采用逻辑回归模型估计非O型（A、B或AB血型）与O型血相比静脉血栓栓塞的比值比（OR）。结果 最终分析纳入226例患者，其中75例（33%）报告有静脉血栓栓塞。在总体样本中，非O型血患者与O型血患者的静脉血栓栓塞之间无显著差异（OR 1.64，95%置信区间（CI）0.94，2.88；P = 0.08）。非O型血男性发生静脉血栓栓塞的风险显著高于O型血男性（OR 4.94，95%CI 1.37，17.85；P = 0.02），但ABO血型与女性静脉血栓栓塞之间无显著关联（OR 0.96，95%CI 0.50，1.83；P = 0.52）。结论 非O血型可能是持续性aPL抗体男性中未被充分认识的静脉血栓栓塞风险因素，而在一般人群中观察到的与非O血型相关的风险在aPL阳性女性中可能减弱。
