中国中老年人群的血清胎球蛋白-A水平与甲状腺功能

Serum Fetuin-A Levels and Thyroid Function inMiddle-aged and Elderly Chinese.

作者信息

Deng Xin Ru, Ding Lin, Wang Tian Ge, Xu Min, Lu Jie Li, Li Mian, Zhao Zhi Yun, Chen Yu Hong, Bi Yu Fang, Xu Yi Ping, Xu Yu

机构信息

State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai 200025, China; Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.

Department of Research and Development, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.

出版信息

Biomed Environ Sci. 2017 Jun;30(6):455-459. doi: 10.3967/bes2017.060.

DOI:10.3967/bes2017.060

PMID:28705270

Abstract

Serum fetuin-A levels are reportedly elevated in hyperthyroidism. However, there are few relevant epidemiologic studies. We conducted a cross-sectional study in Songnan community, China in 2009 to investigate the association between serum fetuin-A concentrations and thyroid function. A total of 2,984 participants aged 40 years and older were analyzed. Multivariable linear regression analysis revealed that serum fetuin-A concentra- tions were positively associated with log (free triiodothyronine) and were inversely associated with log (thyroid peroxidase antibody) after adjustment (both P < 0.05). Compared with the participants in the lowest tertile of free triiodo-thyronine and free thyroxine level, those in the highest tertile had higher fetuin-A concentrations. Additionally, high serum fetuin-A concentrations were related to high thyroid function (odds ratio 1.27, 95% confidence interval 1.01-1.61), after adjustment for conventional risk factors.

摘要

据报道，甲状腺功能亢进症患者血清胎球蛋白-A水平升高。然而，相关的流行病学研究较少。2009年我们在中国松南社区进行了一项横断面研究，以调查血清胎球蛋白-A浓度与甲状腺功能之间的关联。共分析了2984名40岁及以上的参与者。多变量线性回归分析显示，调整后血清胎球蛋白-A浓度与log（游离三碘甲状腺原氨酸）呈正相关，与log（甲状腺过氧化物酶抗体）呈负相关（均P<0.05）。与游离三碘甲状腺原氨酸和游离甲状腺素水平处于最低三分位数的参与者相比，处于最高三分位数的参与者胎球蛋白-A浓度更高。此外，在对传统危险因素进行调整后，高血清胎球蛋白-A浓度与高甲状腺功能相关（比值比1.27，95%置信区间1.01-1.61）。