Tumer Gizem, Jow Tiffany, McElligott Sean, Schwartz Robert A, Lambert W Clark
Departments of Pathology, Rutgers University - New Jersey Medical School, Newark, NJ.
Departments of Dermatology, Rutgers University - New Jersey Medical School, Newark, NJ.
Skinmed. 2017 Jun 1;15(3):171-174. eCollection 2017.
Telangiectasia macularis eruptiva perstans (TMEP) is a rare, heterogeneous disease of mast cell proliferation. The variable clinical presentation of TMEP, coupled with its rarity, makes the recognition and diagnosis of this disease difficult and challenging for clinicians. The histopathologic findings with hematoxylin and eosin staining that distinguish TMEP from a normal skin biopsy can be so subtle that confirmation of the diagnosis with additional special stains (c-Kit, Giemsa, toluidine blue) is strongly recommended. We describe three cases that highlight the variable clinical presentation of TMEP. One patient experienced only a localized skin manifestation, another an aggressive clinical course with systemic involvement, and a third diffuse skin involvement with mild fatigue, muscle pain, and weight gain.
持久性斑状毛细血管扩张性肥大细胞增生病（TMEP）是一种罕见的、异质性的肥大细胞增殖性疾病。TMEP临床表现多样，加之其罕见性，使得临床医生对该病的识别和诊断既困难又具有挑战性。苏木精和伊红染色的组织病理学结果将TMEP与正常皮肤活检区分开来，这些结果可能非常细微，因此强烈建议使用额外的特殊染色（c-Kit、吉姆萨、甲苯胺蓝）来确诊。我们描述了三例突出TMEP临床表现多样性的病例。一名患者仅出现局部皮肤表现，另一名患者临床病程进展迅速且累及全身，第三名患者则出现弥漫性皮肤受累，并伴有轻度疲劳、肌肉疼痛和体重增加。
