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1
Further studies on the mode of action of the heme-controlled translational inhibitor: stimulating protein acts at level of binary complex formation.血红素控制的翻译抑制剂作用模式的进一步研究：刺激蛋白在二元复合物形成水平起作用。
Proc Natl Acad Sci U S A. 1979 May;76(5):2163-4. doi: 10.1073/pnas.76.5.2163.
2
Regulation of protein synthesis in rabbit reticulocyte lysates: additional initiation factor required for formation of ternary complex (eIF-2.GTP.Met-tRNAf) and demonstration of inhibitory effect of heme-regulated protein kinase.兔网织红细胞裂解物中蛋白质合成的调控：三元复合物（eIF-2·GTP·Met-tRNAf）形成所需的额外起始因子以及血红素调节蛋白激酶抑制作用的证明。
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1079-83. doi: 10.1073/pnas.76.3.1079.
3
Protein synthesis in rabbit reticulocytes: characteristics of a postribosomal supernatant factor that reverses inhibition of protein synthesis in heme-deficient lysates and inhibition of ternary complex (Met-tRNAfMet.eIF-2.GTP) formation by heme-regulated inhibitor.兔网织红细胞中的蛋白质合成：一种核糖体后上清因子的特性，该因子可逆转血红素缺乏裂解物中蛋白质合成的抑制以及血红素调节抑制剂对三元复合物（Met-tRNAfMet.eIF-2.GTP）形成的抑制。
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5490-4. doi: 10.1073/pnas.76.11.5490.
4
Mode of action of the heme-controlled translational inhibitor: relationship of eukaryotic initiation factor 2-stimulating protein to translation restoring factor.血红素控制的翻译抑制剂的作用模式：真核起始因子2刺激蛋白与翻译恢复因子的关系。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):220-3. doi: 10.1073/pnas.78.1.220.
5
Further studies on the mode of action of the heme-controlled translational inhibitor.
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1741-5. doi: 10.1073/pnas.76.4.1741.
6
Protein synthesis in rabbit reticulocytes: a study of the mechanism of action of the protein factor RF that reverses protein synthesis inhibition in heme-deficient reticulocyte lysates.兔网织红细胞中的蛋白质合成：对蛋白质因子RF作用机制的研究，该因子可逆转血红素缺乏的网织红细胞裂解物中的蛋白质合成抑制。
Proc Natl Acad Sci U S A. 1984 Sep;81(17):5379-83. doi: 10.1073/pnas.81.17.5379.
7
Protein synthesis in brine shrimp embryos and rabbit reticulocytes. The effect of Mg2+ on binary (eukaryotic initiation factor 2 X GDP) and ternary (eukaryotic initiation factor 2 X GTP X met-tRNAf) complex formation.卤虫胚胎和兔网织红细胞中的蛋白质合成。Mg2+对二元复合物（真核起始因子2×GDP）和三元复合物（真核起始因子2×GTP×甲硫氨酰-tRNAf）形成的影响。
J Biol Chem. 1983 Mar 25;258(6):3438-41.
8
Mechanism of polypeptide chain initiation in eukaryotes and its control by phosphorylation of the alpha subunit of initiation factor 2.真核生物中多肽链起始的机制及其受起始因子2α亚基磷酸化的调控
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2537-40. doi: 10.1073/pnas.79.8.2537.
9
Protein synthesis in rabbit reticulocytes: mechanism of protein synthesis inhibition by heme-regulated inhibitor.兔网织红细胞中的蛋白质合成：血红素调节抑制剂对蛋白质合成的抑制机制。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5076-9. doi: 10.1073/pnas.76.10.5076.
10
Molecular mechanisms of control of protein biosynthesis.蛋白质生物合成调控的分子机制。
Eur J Cell Biol. 1981 Dec;26(1):212-6.

引用本文的文献

1
Protein synthesis in rabbit reticulocytes: characteristics of the protein factor RF that reverses inhibition of protein synthesis in heme-deficient reticulocyte lysates.兔网织红细胞中的蛋白质合成：逆转血红素缺乏的网织红细胞裂解物中蛋白质合成抑制作用的蛋白质因子RF的特性。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6517-21. doi: 10.1073/pnas.79.21.6517.
2
Mechanism of polypeptide chain initiation in eukaryotes and its control by phosphorylation of the alpha subunit of initiation factor 2.真核生物中多肽链起始的机制及其受起始因子2α亚基磷酸化的调控
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2537-40. doi: 10.1073/pnas.79.8.2537.
3
Mode of action of the heme-controlled translational inhibitor: relationship of eukaryotic initiation factor 2-stimulating protein to translation restoring factor.血红素控制的翻译抑制剂的作用模式：真核起始因子2刺激蛋白与翻译恢复因子的关系。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):220-3. doi: 10.1073/pnas.78.1.220.
4
Purification and properties of the double-stranded RNA-activated eukaryotic initiation factor 3 kinase from rabbit reticulocytes.兔网织红细胞双链RNA激活的真核起始因子3激酶的纯化及性质
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6526-30. doi: 10.1073/pnas.77.11.6526.
5
Initiation of protein synthesis in mammalian cells.哺乳动物细胞中蛋白质合成的起始
Biochem J. 1986 May 1;235(3):625-37. doi: 10.1042/bj2350625.

本文引用的文献

1
Binding of MET-TRNAf and GTP to homogeneous initiation factor MP.甲硫氨酰 - 转运核糖核酸f（MET-TRNAf）与鸟苷三磷酸（GTP）与均一化起始因子MP的结合。
J Biol Chem. 1975 Dec 10;250(23):9076-82.
2
Additional evidence that the hemin-controlled translational repressor from rabbit reticulocytes is a protein kinase.来自兔网织红细胞的血红素控制的翻译阻遏物是一种蛋白激酶的更多证据。
Biochem Biophys Res Commun. 1977 Jan 24;74(2):559-69. doi: 10.1016/0006-291x(77)90340-0.
3
Soluble factors required for eukaryotic protein synthesis.真核生物蛋白质合成所需的可溶性因子。
Annu Rev Biochem. 1976;45:191-216. doi: 10.1146/annurev.bi.45.070176.001203.
4
The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.来自兔网织红细胞的蛋白质合成起始因子的作用机制。
J Biol Chem. 1978 May 10;253(9):3078-87.
5
Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.哺乳动物蛋白质合成的起始。II. 起始复合物与纯化起始因子的组装
J Mol Biol. 1977 Nov;116(4):755-67. doi: 10.1016/0022-2836(77)90269-8.
6
Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesis.起始因子elF-2的磷酸化与网织红细胞蛋白质合成的调控
Cell. 1977 May;11(1):187-200. doi: 10.1016/0092-8674(77)90330-0.
7
Further studies on the mode of action of the heme-controlled translational inhibitor.
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1741-5. doi: 10.1073/pnas.76.4.1741.
8
Mode of action of the hemin-controlled inhibitor of protein synthesis: studies with factors from rabbit reticulocytes.血红素控制的蛋白质合成抑制剂的作用模式：对来自兔网织红细胞的因子的研究。
Proc Natl Acad Sci U S A. 1978 Jun;75(6):2713-6. doi: 10.1073/pnas.75.6.2713.
9
Regulation of protein synthesis: activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2.蛋白质合成的调控：双链RNA激活一种使真核起始因子2磷酸化的蛋白激酶。
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1121-5. doi: 10.1073/pnas.75.3.1121.
10
Effect of hemin on site-specific phosphorylation of eukaryotic initiation factor 2.血红素对真核起始因子2位点特异性磷酸化的影响
Proc Natl Acad Sci U S A. 1978 Feb;75(2):789-93. doi: 10.1073/pnas.75.2.789.

血红素控制的翻译抑制剂作用模式的进一步研究：刺激蛋白在二元复合物形成水平起作用。

Further studies on the mode of action of the heme-controlled translational inhibitor: stimulating protein acts at level of binary complex formation.

作者信息

de Haro C, Ochoa S

出版信息

Proc Natl Acad Sci U S A. 1979 May;76(5):2163-4. doi: 10.1073/pnas.76.5.2163.

DOI:10.1073/pnas.76.5.2163
PMID:287053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC383557/
Abstract

Previous work has shown that (i) at physiological concentrations of eukaryotic initiation factor 2 (eIF-2), formation of the ternary complex eIF-2-GTP-Met-tRNAi, which precedes the assembly of a 40S initiation complex, requires the presence of eIF-2 stimulating protein (ESP) and (ii) the interaction of eIF-2 with ESP is blocked by the translational inhibitor which, in reticulocyte lysates, is activated in the absence of hemin. Present evidence indicates that formation of the ternary complex is preceded by formation of the binary complex eIF-2-GTP and that ESP acts at the level of binary complex formation.

摘要

先前的研究表明

（i）在真核起始因子2（eIF-2）的生理浓度下，先于40S起始复合物组装的三元复合物eIF-2-GTP-甲硫氨酰-tRNAi的形成需要eIF-2刺激蛋白（ESP）的存在；（ii）eIF-2与ESP的相互作用被翻译抑制剂阻断，在网织红细胞裂解物中，该抑制剂在无血红素的情况下被激活。目前的证据表明，三元复合物的形成之前先有二元复合物eIF-2-GTP的形成，并且ESP在二元复合物形成水平起作用。