Singh Amrinder, Brooks Desiree D, Abrams Taryn A, Poorak Mitra D, Gunio Drew, Kandhal Prianka K, Lakhanpal Aleena, Sethuraman Sankara N, Bruno Askiel
Department of Neurology, Medical College of Georgia, United States.
Medical College of Georgia, Augusta University, United States.
Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S891-S893. doi: 10.1016/j.dsx.2017.07.011. Epub 2017 Jul 3.
Hyperglycemia in type 2 diabetes mellitus (T2D) remains uncontrolled in approximately 50% of patients in the United States. Uncontrolled T2D is associated with various vascular complications, including stroke. We studied demographic and clinical factors association with pre-stroke glycemia, indicated by glycated hemoglobin (HbA1c), in acute stroke patients with T2D.
Using a questionnaire, we collected demographic, socioeconomic, and clinical information from 300 acute ischemic and hemorrhagic stroke patients in one hospital. We analyzed factors associated with HbA1c in patients with history of T2D.
There were 111 patients with history of T2D and HbA1c measured on admission. In multivariable analyses factors associated with higher HbA1c were treatment with insulin (p=0.05), history of hyperlipidemia (p=0.01), and total cholesterol level (p=0.02). Poor adherence to T2D treatment was associated with higher HbA1c levels (p=0.006) only in a subgroup of patients with HbA1c ≥8%.
Insulin treatment and hyperlipidemia are associated with higher HbA1c levels in acute stroke patients with T2D. Poor adherence to diabetes treatment is associated with higher HbA1c levels only among patients with HbA1c ≥8%.
在美国，约50%的2型糖尿病（T2D）患者的高血糖仍未得到控制。未得到控制的T2D与包括中风在内的各种血管并发症相关。我们研究了T2D急性中风患者中与糖化血红蛋白（HbA1c）所指示的中风前血糖相关的人口统计学和临床因素。
我们使用一份问卷，从一家医院的300名急性缺血性和出血性中风患者中收集了人口统计学、社会经济和临床信息。我们分析了有T2D病史患者中与HbA1c相关的因素。
有111名有T2D病史且入院时测量了HbA1c的患者。在多变量分析中，与较高HbA1c相关的因素有胰岛素治疗（p = 0.05）、高脂血症病史（p = 0.01）和总胆固醇水平（p = 0.02）。仅在HbA1c≥8%的患者亚组中，对T2D治疗的依从性差与较高的HbA1c水平相关（p = 0.006）。
胰岛素治疗和高脂血症与T2D急性中风患者较高的HbA1c水平相关。仅在HbA1c≥8%的患者中，对糖尿病治疗的依从性差与较高的HbA1c水平相关。
