猪结肠外植体对体外感染的代谢反应：迈向疾病病理生理学的飞跃。 （注：原文中“by”后面似乎缺少具体内容）
Metabolic response of porcine colon explants to in vitro infection by : a leap into disease pathophysiology.
作者信息
Welle Thijs, Hoekstra Anna T, Daemen Ineke A J J M, Berkers Celia R, Costa Matheus O
机构信息
Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands.
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.
出版信息
Metabolomics. 2017;13(7):83. doi: 10.1007/s11306-017-1219-6. Epub 2017 May 30.
INTRODUCTION
Swine dysentery caused by is a production limiting disease in pig farming. Currently antimicrobial therapy is the only treatment and control method available.
OBJECTIVE
The aim of this study was to characterize the metabolic response of porcine colon explants to infection by .
METHODS
Porcine colon explants exposed to were analyzed for histopathological, metabolic and pro-inflammatory gene expression changes.
RESULTS
Significant epithelial necrosis, increased levels of l-citrulline and IL-1α were observed on explants infected with .
CONCLUSIONS
The spirochete induces necrosis in vitro likely through an inflammatory process mediated by IL-1α and NO.
引言
由[未提及病原体名称]引起的猪痢疾是养猪业中一种限制生产的疾病。目前，抗菌治疗是唯一可用的治疗和控制方法。
目的
本研究的目的是表征猪结肠外植体对[未提及病原体名称]感染的代谢反应。
方法
分析暴露于[未提及病原体名称]的猪结肠外植体的组织病理学、代谢和促炎基因表达变化。
结果
在感染[未提及病原体名称]的外植体上观察到明显的上皮坏死、L-瓜氨酸和IL-1α水平升高。
结论
螺旋体可能通过IL-1α和NO介导的炎症过程在体外诱导坏死。
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